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Razvoj bioaktivnih molekula za tretman neurodegenerativnih bolesti (BioMol4ND)

Voditelj projekta: Anita Bosak

Istraživački tim

PUBLIKACIJE

Radovi u časopisima
  • J. Kesić, M. Popsavin, G. Benedeković, V. Kojić, A. Bosak, A. Matošević, P. Farkaš, R. Madelová, V. Popsavin, I. Kovačević. Synthesis and biological evaluation of natural cleistanolate, its enantiomer and analogues. European Journal of Medicinal Chemistry, 2025,287,117326. doi: 10.1016/j.ejmech.2025.117326
  • K. Komatović, A. Matošević, M. Zlatović, D. Sladić, A. Bosak, D. Opsenica. Hybrids of 4-aminoquinolines and adamantane as inhibitors of AChE. Journal of the Serbian Chemical Society. 2025, prihvaćen za objavljivanje, doi:10.2298/JSC250131014K
  • M. Bartolić, A. Bosak. Overview of BACE1 structure and effect of genetic polymorphisms and protein isoforms on enzyme activity. Periodicum biologorum. 2024, prihvaćen za objavljivanje. doi:10.18054/pb.v126i3-4.33903.
  • M. Bartolić, A. Matošević, N. Maraković, V. Bušić, S. Roca, D. Vikić-Topić, A. Sabljić, A. Bosak, D. Gašo-Sokač. Evaluation of hydrazone and N-acylhydrazone derivatives of vitamin B6 and pyridine-4-carbaldehyde as potential drugs against Alzheimer’s disease. Journal of Enzyme Inhibition and Medicinal Chemistry. 2024,39(1). doi: 10.1080/14756366.2024.2431832
  • A. Matošević, D. Opsenica, M. Bartolić, N. Maraković, A. Stoilković, K. Komatović, A. Zandona, S. Žunec, A. Bosak. Derivatives of amodiaquine as potent human cholinesterases inhibitors: Implication for treatment of Alzheimer’s disease. Molecules. 2024,29(2),5357. doi: 10.3390/molecules29225357
  • A. Matošević, M. Bartolić, N. Maraković, A. Zandona, R. Petrić, D.M. Opsenica, A. Bosak, Synthesis and biological evaluation of novel aminoquinolines with an n-octyl linker: Impact of halogen substituents on C(7) or a terminal amino group on anticholinesterase and BACE1 activity. Bioorganic & Medicinal Chemistry Letters 2024, 112, 129928. doi: 10.1016/j.bmcl.2024.129928
  • A. Matošević, D.M. Opsenica, M. Spasić, N. Maraković, A. Zandona, S. Žunec, M. Bartolić, Z. Kovarik, A. Bosak, Evaluation of 4-aminoquinoline derivatives with an n-octylamino spacer as potential multi-targeting ligands for the treatment of Alzheimer’s disease, Chemico-biological Interactions 2023, 382, 110620. doi: 10.1016/j.cbi.2023.110620
  • A. Matošević, A Knežević, A. Zandona, N. Maraković, Z. Kovarik, A. Bosak, Design, synthesis and biological evaluation of biscarbamates as potential selective butyrylcholinesterase inhibitors for the treatment of Alzheimer’s disease, Pharmaceuticals 2022, 15, 1220. doi:10.3390/ph15101220 (IF (2021) = 5,21; Q1)
  • K. Komatović, A. Matošević, N. Terzić-Jovanović, S. Žunec, S. Šegan, M. Zlatović, N. Maraković, A. Bosak, D. Opsenica, 4-aminoquinoline-based adamantanes as potential anticholinesterase agents in symptomatic treatment of Alzheimer’s disease. Pharmaceutics 2022, 14, 1305. doi:10.3390/pharmaceutics14061305 (IF= 6,52 (2021); Q1)
  • A. Matošević, A. Radman Kastelic, A. Mikelić, A. Zandona, M. Katalinić, I. Primožič, A. Bosak, T. Hrenar, Quinuclidine-based carbamates as potential CNS active compounds, Pharmaceutics, 13 (2021), 3; 420, 15 doi:10.3390/pharmaceutics13030420 (IF (2020) =6,52;  Q1).
Sudjelovanje na skupovima:
Predavanja
  • A. Bosak. Development of bioactive molecules for neurodegenerative disease treatment. Mini-symposium: Multidisciplinarity in drug development, Zagreb, 12.2.2025. (sažetak)
  • M. Bartolić, A. Bosak. Multi-target approach to the treatment of Alzheimer’s disease: revival of amyloid theory. Mini-symposium: Multidisciplinarity in drug development, Zagreb, 12.2.2025. (sažetak)
  • A. Matošević, Development of carbamate-based compounds as potential cholinesterase inhibitors for the treatment of Alzheimer`s disease. Mini-symposium: Multidisciplinarity in drug development, Zagreb, 12.2.2025. (sažetak)
  • K. Komatović, N. Terzić-Jovanović, M. Zlatović, A. Matošević, N. Maraković, D. Opsenica, A. Bosak. Adamantane derivatives of 4-aminoquinoline as inhibitors of hAChE and hBChE: design and synthesis. Mini-symposium: Multidisciplinarity in drug development, Zagreb, 12.2.2025. (sažetak)
  • A. Zandona. Cytotoxicity of aminoquinoline and carbamate cholinesterase inhibitors. Mini-symposium: Multidisciplinarity in drug development, Zagreb, 12.2.2025. (sažetak)
  • S. Žunec. Antioxidant testing in development of multifunctional drug candidates for neurodegenerative diseases. Mini-symposium: Multidisciplinarity in drug development, Zagreb, 12.2.2025. (sažetak)
  • S. Šegan, M. Zlatović, N. Maraković, A. Bosak, D. Opsenica. QSAR insights in 4-aminoquinoline derivatives as AChE and BChE inhibitors. Mini-symposium: Multidisciplinarity in drug development, Zagreb, 12.2.2025. (sažetak)
  • M. Bartolić, D. Gašo Sokač, V. Bušić, A. Ramić, I. Primožič, A. Bosak. Comparison of structurally different ligands’ ability to prevent amyloid formation in Alzheimer’s disease. FEBS3+ Meeting Exploring Molecular Frontiers. Pula, 25.-28.9.2024.
  • A. Bosak, A. Matošević, I. Primožič. Carbamates – A privileged pharmacophore in the design of potent cholinesterase inhibitors for treating alzheimer’s disease. FEBS3+ Meeting Exploring Molecular Frontiers. Pula, 25.-28.9.2024.
  • A. Matošević, N. Maraković, Z. Kovarik, A. Bosak. BChE polymorphism effect on the efficiency of 5-(2-amino-1-hydroxyethyl) phenol carbamates as potential new drugs for advanced Alzheimer`s disease treatment. FEBS3+ Meeting Exploring Molecular Frontiers. Pula, 25.-28.9.2024.
  • A. Matošević, A. Bosak. Synthesis and biological evaluation of carbamate derivatives of 3-(2-amino-1-hydroxyethyl) phenol as potential drugs for the treatment of Alzheimer`s disease. 11th EFMC Young Medicinal Chemists’ Symposium & The XXVIII EFMC International Symposium on Medicinal Chemistry, Rim, Italija, 1.-.9.2024.
  • M. Bartolić, A. Bosak. Prospect for development of Alzheimer’s disease drugs based on 4-aminoquinoline scaffold, 11th EFMC Young Medicinal Chemists’ Symposium & The XXVIII EFMC International Symposium on Medicinal Chemistry, Rim, Italija, 1.-.9.2024.
  • M. Bartolić, D. Gašo-Sokač, V. Bušić, A. Ramić, I. Primožič, A Bosak, Amyloid-targeting approach for treatment of Alzheimer’s disease: biological evaluation of different structural scaffolds. 8th Faculty of Science PhD Student Symposium, Zagreb, 2024.
  • M. Bartolić, A. Bosak. Small Molecules, Big Dreams: In Search of Multi-Target Directed Ligands for the Treatment of Alzheimer’s Disease. 9th Conference of Young Chemists of Serbia, Novi Sad, Srbija, 2023.
  • M. Bartolić, P. Šušak, M. Arežina, M. Laučan, A. Ramić, T. Hrenar, I. Primožič, A. Bosak. Quinuclidinium based O-alkyl oximes as potential anticholinesterase agents in symptomatic treatment of Alzheimer’s disease. 10th EFMC Young Medicinal Chemists’ Symposium & IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry. Zagreb, 2023.
  • I. Novaković, A. Matošević, V. Milovanović, M. Bartolić, D. Opsenica, D. Sladić, A. Bosak. 1,4-benzoquinones as potent agents for Alzheimer`s disease treatment. IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry. Zagreb, 2023.
  • A. Bosak, A. Matošević, D.M. Opsenica, N. Maraković, A. Zandona, S. Žunec, M. Bartolić, S. Šegan. N-octylamino derivatives of 4-aminoquinoline as possible multifuctional agents for Alzheimer`s disease treatment. IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry. Zagreb, 2023.
  • A. Matošević, A. Bosak, A. Zandona, N. Maraković. Carbamates as potential new drugs in the treatment of Alzheimer`s disease. IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry &10th EFMC Young Medicinal Chemist`s Symposium. Zagreb, 2023.
  • M. Bartolić, A. Matošević, M. Spasić, D. Opsenica, A. Bosak. Evaluation of 4-aminoquinolines as potential MTDL ligands for the treatment of Alzheimer`s disease, Joint IUBMB/FEBS Advanced Lecture Course “Molecular targets for anti-aging interventions” Spetses Island, Grčka, 26.9.-1.10.2022.
  • A. Matošević, A. Knežević, A. Zandona, N. Maraković, Z. Kovarik, A. Bosak. Design, synthesis and biological evaluation of biscarbamates as potentialselective butyrylcholinesterase inhibitors for the treatment of Alzheimer`s disease, Joint IUBMB/FEBS Advanced Lecture Course “Molecular targets for anti-aging interventions”, Spetses Island, Grčka, 26.9.-1.10.2022.
  • K. Komatović, A. Matošević, M. Spasić, N. Maraković, A. Bosak, D. Opsenica. Synthesis and biological evaluation of 4-amino-7- chloroquinolines as novel reversible inhibitors of human cholinesterases, Congress of the Croatian Society of Biochemistry and Molecular Biology HDBMB22: From Science to Knowledge, Brela, Hrvatska 28.9.-1.10.2022.
  • M. Bartolić, A. Matošević, V. Bušić, D. Gašo Sokač, A. Bosak. Evaluation of hydrazone-based compounds as potential drugs for treatment of Alzheimer’s disease, European School of Medicinal Chemistry- 41st Advanced Course of Medicinal Chemistry and “E. Duranti” Seminar for PhD Students, Urbino, Italija, 3.-7.7. 2022.
  • A. Matošević, A. Knežević, N. Maraković, Z. Kovarik, A. Bosak. Design, synthesis and biological evaluation of cyclic biscarbamates as selective butyrylcholinesterase inhibitors in the treatment of Alzheimer`s disease, European School of Medicinal Chemistry- 41st Advanced Course of Medicinal Chemistry and “E. Duranti” Seminar for PhD Students, Urbino, Italija, 3.-7.7. 2022.
  • M. Bartolić, A. Matošević, V. Bušić, D. Gašo-Sokač, A. Bosak. Hydrazone-based compounds evaluated as inhibitors of human cholinesterases, 17th International Symposium on Cholinergic Mechanisms (ISCM2022), 17th International Symposium on Cholinergic Mechanisms (ISCM2022), Dubrovnik, 8.-12.5.2022.
  • A. Matošević, A. Knežević, A. Zandona, N. Maraković, M. Katalinić, Z. Kovarik, A. Bosak. Synthesis and biological evaluation of heterocyclic meta-biscarbamates, 17th International Symposium on Cholinergic Mechanisms (ISCM2022), Dubrovnik, 2022.
  • D. Opsenica, A. Bosak, A. Matošević, K. Komatović, N. Maraković. 4-aminoquinolines, a privileged pharmacophore- from antimalarials to inhibition of cholinesterase. Book of Abstracts of the 27th Croatian Meeting of Chemists and Chemical Engineers (27HSKIKI). Veli Lošinj, Hrvatska. 5.-8.10.2021. (sažetak)
  • A. Matošević, A. Bosak. Application of NMR for monitoring the synthetic route and characterization of bisacrbamates. The Adriatic NMR Conference 2021. Primošten, Hrvatska. 13.-15.9.2021.; str. 46. (poster, sažetak)
  • K. Komatović, A. Matošević, N. Terzić- Jovanović, A. Bosak, D. Opsenica. Adamantane based derivatives as reversible inhibitors of human AChE and BChE. FEBS Open Bio 11 (Suppl. 1); 45th FEBS Congress, Molecules of Life: Towards New Horizons. Ljubljana, Slovenija. 3.-8. 7. 2021.; str. 213. (poster)
  • A. Bosak, A. Matošević, A. Zandona, G. Šinko, K. Komatović, D. Opsenica. New 4-aminoquinoline-based cholinesterase inhibitors. FEBS Open Bio (Suppl. 1); 45th FEBS Congress, Molecules of Life: Towards New Horizons. Ljubljana, Slovenija. 3.–8. 7. 2021.; str. 310.-311. (poster, sažetak)
  • A. Matošević, A. Knežević, A. Bosak. Heterocyclic carbamates as potential drugs for the treatment of the neurodegenrative diseases. The 29th European Colloquium on Heterocyclic Chemistry. Rouen, Francuska, 26-28. 4. 2021.; str. 143. (poster, sažetak)
  • A. Matošević, A. Bosak. Design, synthesis and biological evaluation of compounds as active drugs in the central and peripheral nervous system. 5. Simpozij studenata doktorskih studija PMF-a, Zagreb, Hrvatska, 24-25. 4. 2021.; str. 146. (poster, sažetak)
Popis publikacija

BioMol4ND

Posterska priopćenja
  • M. Bartolić, D. Gašo Sokač, V. Bušić, A. Ramić, I. Primožič, A. Bosak. Comparison of structurally different ligands’ ability to prevent amyloid formation in Alzheimer’s disease. FEBS3+ Meeting Exploring Molecular Frontiers. Pula, 2024.
  • A. Bosak, A. Matošević, I. Primožič. Carbamates – A privileged pharmacophore in the design of potent cholinesterase inhibitors for treating alzheimer’s disease. FEBS3+ Meeting Exploring Molecular Frontiers. Pula, 2024.
  • A. Matošević, N. Maraković, Z. Kovarik, A. Bosak. BChE polymorphism effect on the efficiency of 5-(2-amino-1-hydroxyethyl) phenol carbamates as potential new drugs for advanced Alzheimer`s disease treatment. FEBS3+ Meeting Exploring Molecular Frontiers. Pula, 2024.
  • A. Matošević, A. Bosak. Synthesis and biological evaluation of carbamate derivatives of 3-(2-amino-1-hydroxyethyl) phenol as potential drugs for the treatment of Alzheimer`s disease. 11th EFMC Young Medicinal Chemists’ Symposium & The XXVIII EFMC International Symposium on Medicinal Chemistry, Rim, Italija, 2024.
  • M. Bartolić, A. Bosak. Prospect for development of Alzheimer’s disease drugs based on 4-aminoquinoline scaffold. The XXVIII EFMC International Symposium on Medicinal Chemistry, Rim, Italija, 2024.
  • M. Bartolić, Alma Ramić, Tomica Hrenar, Ines Primožič, Anita Bosak. Quinuclidinium oximes as cholinesterases’ and amyloid formation inhibitors. EMBO Workshop: Molecular Neurobiology 2024, Heraklion, Grčka, 2024.
  • M. Bartolić, D. Gašo-Sokač, V. Bušić, A. Ramić, I. Primožič, A Bosak, Amyloid-targeting approach for treatment of Alzheimer’s disease: biological evaluation of different structural scaffolds. 8th Faculty of Science PhD Student Symposium, Zagreb, 2024.
  • M. Bartolić, A. Bosak. Small Molecules, Big Dreams: In Search of Multi-Target Directed Ligands for the Treatment of Alzheimer’s Disease. 9th Conference of Young Chemists of Serbia, Novi Sad, Srbija, 2023.
  • A. Matošević, A. Bosak. Design, synthesis and biological evaluation of carbamates as cholinesterases inhibitors in the treatment of Alzheimer`s disease. 9th Conference of Young Chemists of Serbia. Novi Sad, Srbija, 2023.
  • M. Bartolić, P. Šušak, M. Arežina, M. Laučan, A. Ramić, T. Hrenar, I. Primožič, A. Bosak. Quinuclidinium based O-alkyl oximes as potential anticholinesterase agents in symptomatic treatment of Alzheimer’s disease. 10th EFMC Young Medicinal Chemists’ Symposium & IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry. Zagreb, 2023.
  • I. Novaković, A. Matošević, V. Milovanović, M. Bartolić, D. Opsenica, D. Sladić, A. Bosak. 1,4-benzoquinones as potent agents for Alzheimer`s disease treatment. IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry. Zagreb, 2023.
  • A. Bosak, A. Matošević, D.M. Opsenica, N. Maraković, A. Zandona, S. Žunec, M. Bartolić, S. Šegan. N-octylamino derivatives of 4-aminoquinoline as possible multifuctional agents for Alzheimer`s disease treatment. IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry. Zagreb, 2023.
  • A. Matošević, A. Bosak, A. Zandona, N. Maraković. Carbamates as potential new drugs in the treatment of Alzheimer`s disease. IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry &10th EFMC Young Medicinal Chemist`s Symposium. Zagreb, 2023.
  • M. Bartolić, A. Matošević, M. Spasić, D. Opsenica, A. Bosak. Evaluation of 4-aminoquinolines as potential MTDL ligands for the treatment of Alzheimer`s disease, Joint IUBMB/FEBS Advanced Lecture Course “Molecular targets for anti-aging interventions” Spetses Island, Grčka, 2022.
  • A. Matošević, A. Knežević, A. Zandona, N. Maraković, Z. Kovarik, A. Bosak. Design, synthesis and biological evaluation of biscarbamates as potentialselective butyrylcholinesterase inhibitors for the treatment of Alzheimer`s disease, Joint IUBMB/FEBS Advanced Lecture Course “Molecular targets for anti-aging interventions”, Spetses Island, Grčka, 2022.
  • K. Komatović, A. Matošević, M. Spasić, N. Maraković, A. Bosak, D. Opsenica. Synthesis and biological evaluation of 4-amino-7- chloroquinolines as novel reversible inhibitors of human cholinesterases, Congress of the Croatian Society of Biochemistry and Molecular Biology HDBMB22: From Science to Knowledge, Brela, Hrvatska, 2022.
  • M. Bartolić, A. Matošević, V. Bušić, D. Gašo Sokač, A. Bosak. Evaluation of hydrazone-based compounds as potential drugs for treatment of Alzheimer’s disease, European School of Medicinal Chemistry- 41st Advanced Course of Medicinal Chemistry and “E. Duranti” Seminar for PhD Students, Urbino, Italija, 2022.
  • A. Matošević, A. Knežević, N. Maraković, Z. Kovarik, A. Bosak. Design, synthesis and biological evaluation of cyclic biscarbamates as selective butyrylcholinesterase inhibitors in the treatment of Alzheimer`s disease, European School of Medicinal Chemistry- 41st Advanced Course of Medicinal Chemistry and “E. Duranti” Seminar for PhD Students, Urbino, Italija, 2022.
  • M. Bartolić, A. Matošević, V. Bušić, D. Gašo-Sokač, A. Bosak. Hydrazone-based compounds evaluated as inhibitors of human cholinesterases, 17th International Symposium on Cholinergic Mechanisms (ISCM2022), 17th International Symposium on Cholinergic Mechanisms (ISCM2022), Dubrovnik, 2022.
  • A. Matošević, A. Knežević, A. Zandona, N. Maraković, M. Katalinić, Z. Kovarik, A. Bosak. Synthesis and biological evaluation of heterocyclic meta-biscarbamates, 17th International Symposium on Cholinergic Mechanisms (ISCM2022), Dubrovnik, 2022.
  • D. Opsenica, A. Bosak, A. Matošević, K. Komatović, N. Maraković. 4-aminoquinolines, a privileged pharmacophore- from antimalarials to inhibition of cholinesterase. Book of Abstracts of the 27th Croatian Meeting of Chemists and Chemical Engineers (27HSKIKI). Veli Lošinj, Hrvatska. 2021.
  • A. Matošević, A. Bosak. Application of NMR for monitoring the synthetic route and characterization of bisacrbamates. The Adriatic NMR Conference 2021. Primošten, Hrvatska. 2021.
  • K. Komatović, A. Matošević, N. Terzić- Jovanović, A. Bosak, D. Opsenica. Adamantane based derivatives as reversible inhibitors of human AChE and BChE. FEBS Open Bio 11 (Suppl. 1); 45th FEBS Congress, Molecules of Life: Towards New Horizons. Ljubljana, Slovenija. 2021.
  • A. Bosak, A. Matošević, A. Zandona, G. Šinko, K. Komatović, D. Opsenica. New 4-aminoquinoline-based cholinesterase inhibitors. FEBS Open Bio (Suppl. 1); 45th FEBS Congress, Molecules of Life: Towards New Horizons. Ljubljana, Slovenija. 2021.
  • A. Matošević, A. Knežević, A. Bosak. Heterocyclic carbamates as potential drugs for the treatment of the neurodegenrative diseases. The 29th European Colloquium on Heterocyclic Chemistry. Rouen, Francuska, 2021.
  • A. Matošević, A. Bosak. Design, synthesis and biological evaluation of compounds as active drugs in the central and peripheral nervous system. 5. Simpozij studenata doktorskih studija PMF-a, Zagreb, Hrvatska, 2021.
Novi projekti
  • A. Matošević. Potpora Zaklade Hrvatske akademije znanosti i umjetnosti za projekt „Sinteza i biološka evaluacija karbamata kao potencijalnih inhibitora kolinesteraza u tretmanu Alzheimerove bolesti“
Nagrade/priznanja/stipendije
  • M. Bartolić. Godišnja nagrada Hrvatskog kemijskog društva za mlade medicinske i farmaceutske kemičare za 2023.
  • M. Bartolić. EMBO Mol Neuro 2024 – travel grant za sudjelovanje na EMBO Workshop Molecular neurobiology, 2024, Heraklion, Grčka
  • A. Matošević. Stipendija European Federation for Medicinal Chemistry za sudjelovanje na XXVIII EFMC International Symposium on Medicinal Chemistry & EFMC- Young Medicinal Chemists’ Symposium, 2024, Rim, Italija
  • M. Bartolić. Stipendija Hrvatskog kemijskog društva za sudjelovanje na XXVIII EFMC International Symposium on Medicinal Chemistry, 2024, Rim, Italija
  • A. Matošević. Stipendija Hrvatskog društva za biokemiju i molekularnu biologiju za sudjelovanje na FEBS3+ Meeting: Exploring molecular Frontiers, 2024. Pula, Hrvatska
  • A. Matošević. Stipendija Hrvatskog kemijskog društva za sudjelovanje na Xth EFMC Young Chemist`s Symposium, 2023, Zagreb, Hrvatska
  • A. Matošević. FEBS Travel Grant za sudjelovanje na Joint IUBMB/FEBS Advanced Lecture Course Molecular Targets for Anti-aging Interventions, 2022, Spetses Island, Grčka
  • A. Matošević. The Young ISN Neurochemistry Award za sudjelovanje na 17th International Symposium on Cholinergic Mechanisms, 2022, Dubrovnik, Hrvatska
Organizacije događanja
  • Simpozij povodom završetka projekta 9343. Mini-symposium: Multidisciplinarity in drug development, Zagreb, 12.2.2025., Institut za medicinska istraživanjai medicinu rada. Organizatori: A. Bosak, A. Matošević i M. Bartolić
Nastavna djelatnost (diplomski radovi, stručne prakse)
  • 2024. Diplomski rad studentice Kemije na Prirodoslovno- matematičkom fakultetu u Zagrebu Petre Šušak “Inhibicija humanih kolinesteraza O-alkiloksimima”- mentorica dr. sc. A. Bosak, neposredna voditeljica M. Bartolić, mag. chem.
  • 2023. Diplomski rad studentice Kemije na Prirodoslovno- matematičkom fakultetu u Zagrebu Aleksandrine Vodolšak “Sinteza i biološka evaluacija heterocikličkih karbamata kao inhibitora humanih kolinesterazaima”- mentorica dr. sc. A. Bosak, neposredna voditeljica dr. sc. A. Matošević
  • 2023. Stručna praksa studentice Kemije na Prirodoslovno- matematičkom fakultetu u Zagrebu Petre Šušak“- mentorica dr. sc. A. Matošević
  • 2021. Stručna praksa studentice Kemije na Prirodoslovno- matematičkom fakultetu u Zagrebu Aleksandrina Vodolšak “- mentorica dr. sc. A. Matošević
  • 2021. Sudjelovanje u održavanju kolegija Praktikum biokemije studentima III. godine Prediplomskog studija Kemije na Prirodoslovno-matematičkom fakultetu u Zagrebu- dr. sc. A. Matošević
Popularizacija znanosti i projekta
  • A. Matošević. Predavanje “Dizajn, sinteza i evaluacija potencijalnih lijekova -primjer Alzheimerove bolesti”, Prirodoslovna škola Karlovac, Karlovac 14.4.2025.
  • A. Matošević. Dani otvorenih vrata IMI. Obilazak laboratorija uz demonstraciju rada,IMI, Zagreb, 22.11.2024. Učenici osnovnih i srednjih škola te studenti.
  • A. Matošević. Organska kemija na IMI-ju. Obilazak laboratorija uz demonstraciju rada, IMI, Zagreb, 14.11.2024. Maturanti Gimazije Daruvar
  • M. Bartolić, A. Matošević. Dan karijera PMF-a WISe – WorkIn’ Science, PMF, Zagreb, 5.11.2024.
  • M. Bartolić. Je li znanstveni rad težak? Radionica, IMI, Zagreb, 22.3.2024. Učenici 8. r.
Radionice/tečajevi/webinari
  • M. Bartolić; ERASMUS+ ToxLearn4EU Summer School, Hasselt, Belgija, 29.6. – 6.7.2024.
  • M. Bartolić; EMBO Workshop: Molecular Neurobiology 2024, Heraklion, Grčka, 13. – 17.5.2024.
  • M. Bartolić, A. Matošević; EU-OPENSCREEN Autumn training school 2023 on topics related to Chemical biology & Drug discovery, 20.-22.11.2023. (on-line)
  • M. Bartolić, A. Matošević; International training on cell culture cultivation and cell-assay performance, 1.-12.10.2023., Zagreb, Hrvatska
  • M. Bartolić, A. Bosak, A. Matošević; Shimadzu radionica “Nexera LC-40 with PDA detector- Theory, LabSolution software, maintenance, troubleshooting”, 15.-17.2.2023., Zagreb, Hrvatska
  • A. Bosak, A. Matošević; FDA Clinical Investigator Training Course, U. S. Food & Drug Administration, 7.-8.12.2022. (on-line)
  • M. Bartolić, A. Bosak, A. Matošević; 1st Workshop in Mass Spectrometry in Life Sciences, Prirodoslovno-matematički fakultet, Zagreb, 24.-26.11.2022.
  • M. Bartolić, A. Matošević; Uvod u molekulsko modeliranje, Institut “Ruđer Bošković”, Zagreb, 2.-6.12.2021.
  • M. Bartolić, Education workshop – Better skills for better jobs: excellent lab book for an excellent career, 11.-12.11.2021. (on-line)
  • A. Bosak; seminar Uvod u upravljanje projektima, Bicro Biocentar, Zagreb, 26. 10. 2021.
  • M. Bartolić, A. Matošević; Praktična radionica Tekućinska kromatografija i spektrometrija masa, BICRO BIOCentar d.o.o., Zagreb 12.-13.10.2021.
  • A. Matošević; SPICA Virtual Session The importance of Chromatography in the Development of Vaccines, 14.10.2021. (on-line)
  • A. Matošević; 2nd Symeres Precision Chemistry Conference on Tools for Molecular Recognition and Diagnostics, 12.-13.10.2021. (on-line)
  • A. Matošević; Reaxys webinar, Hrvatsko kemijsko društvo i Elsevier, 23.04.2021.
  • A. Matošević, webinar, Intact and peptide level characterization of nanobodies by high resolution HPLC-MS/MS, 12.2.2021.
Projekt u slikama…

A. Matošević (lijevo) i M. Bartolić (desno), Joint IUBMB/FEBS Advanced Lecture Course “Molecular targets for anti-aging interventions”, Spetses Island, Grčka, 2022.

A. Matošević (lijevo) i M. Bartolić (desno), European School of Medicinal Chemistry- 41st Advanced Course of Medicinal Chemistry and “E. Duranti” Seminar for PhD Students , Urbino, Italija, 2022.

A. Bosak, A.Matošević i M. Bartolić (s lijeva) 17th International Symposium on Cholinergic Mechanism, Dubrovnik

A. Matošević; 5. Simpozij studenata doktorskih studija PMF-a, Zagreb, Hrvatska, 2021.