IMI - Webmail

Razvoj bioaktivnih molekula za tretman neurodegenerativnih bolesti (BioMol4ND)

Voditelj projekta: Anita Bosak

Istraživački tim

Izvedbeni plan projektnih aktivnosti

PUBLIKACIJE

Radovi u časopisima
  1. Matošević, M. Bartolić, N. Maraković, A. Zandona, R. Petrić, D.M. Opsenica, A. Bosak, Synthesis and biological evaluation of novel aminoquinolines with an n-octyl linker: Impact of halogen substituents on C(7) or a terminal amino group on anticholinesterase and BACE1 activity. Bioorganic & Medicinal Chemistry Letters 2024, 112, 129928. doi: 10.1016/j.bmcl.2024.129928
  2. Matošević, D.M. Opsenica, M. Spasić, N. Maraković, A. Zandona, S. Žunec, M. Bartolić, Z. Kovarik, A. Bosak, Evaluation of 4-aminoquinoline derivatives with an n-octylamino spacer as potential multi-targeting ligands for the treatment of Alzheimer’s disease, Chemico-biological Interactions 2023, 382, 110620. doi: 10.1016/j.cbi.2023.110620
  3. Matošević, A Knežević, A. Zandona, N. Maraković, Z. Kovarik, A. Bosak, Design, synthesis and biological evaluation of biscarbamates as potential selective butyrylcholinesterase inhibitors for the treatment of Alzheimer’s disease, Pharmaceuticals 2022, 15, 1220. doi:10.3390/ph15101220 (IF (2021) = 5,21; Q1)
  4. Komatović, A. Matošević, N. Terzić-Jovanović, S. Žunec, S. Šegan, M. Zlatović, N. Maraković, A. Bosak, D. Opsenica, 4-aminoquinoline-based adamantanes as potential anticholinesterase agents in symptomatic treatment of Alzheimer’s disease. Pharmaceutics 2022, 14, 1305. doi:10.3390/pharmaceutics14061305 (IF= 6,52 (2021); Q1)
  5. A. Matošević, A. Radman Kastelic, A. Mikelić, A. Zandona, M. Katalinić, I. Primožič, A. Bosak, T. Hrenar, Quinuclidine-based carbamates as potential CNS active compounds, Pharmaceutics, 13 (2021), 3; 420, 15 doi:10.3390/pharmaceutics13030420 (IF (2020) =6,52;  Q1).
Sudjelovanje na skupovima:
Predavanja
  • A. Bosak, A. Matošević, M. Bartolić, I. Primožič, A. Ramić, X. Brazzolotto, F. Nachon, N. Maraković. Detection of selective inhibitors of BChE in structurally and functionally different group of molecules. 15th International Meeting on Cholinesterases, 9th International Meeting on Paraoxonases (ChE-PON 2024). Brdo pri Kranju, Slovenija. 2024. (pozvano predavanje)
  • M. Bartolić, A. Bosak. Prospect for development of Alzheimer’s disease drugs based on 4-aminoquinoline scaffold, 11th EFMC Young Medicinal Chemists’ Symposium & The XXVIII EFMC International Symposium on Medicinal Chemistry, Rim, Italija, 2024. (pozvano predavanje)
  • J. Kesić, M. Popsavin, G. Benedeković, V. Kojić, A. Bosak, A. Matošević, A. Popsavin, V. Kovačević. Influence of ester groups to biological activity of cleistanolate analogues, 60th Meeting of the Serbian Chemical Society, Niš, Srbija, 2024.
  • A. Bosak. Alzheimerova bolest: ima li nade?Tjedan karijera Sveučilišta u Osijeku, Kemijski odsjek Sveučlišta u Osijeku, Osijek
  • M. Bartolić, A. Bosak. Multiple Problems, One Solution: Multi-Target Directed Ligands as the Future Treatment for Alzheimer’s Disease. 7th Mini Symposium of Section of Medicinal and Pharmaceutical Chemistry. Zagreb, 2023.
  • A. Bosak. Cholinesterase inhibitors as drugs for Alzheimer’s disease. 59th Meeting of the Serbian Chemical Society. Novi Sad, Srbija, 2023. (plenarno predavanje)
  • A. Matošević, A. Bosak. Design, synthesis and biological evaluation of carbamates as cholinesterases inhibitors in the treatment of Alzheimer`s disease. 9th Conference of Young Chemists of Serbia. Novi Sad, Srbija, 2023.
  • A. Matošević, A. Bosak, A. Zandona, N. Maraković. Carbamates as potential new drugs in the treatment of Alzheimer`s disease. 10th EFMC Young Medicinal Chemist`s Symposium. Zagreb, 2023.
  • A. Bosak, Development of bioactive molecules for treatment of Alzheimer’s diseases, Symposium „Cell-Based Research in Toxicology and Drug Design”, Zagreb, 2023.
  • A. Matošević, A. Zandona, N. Maraković, Z. Kovarik, A. Bosak. Design and synthesis of selective butyrylcholinesterase inhibitors as multi- target directed ligands in the treatment of Alzheimer’s disease, 6th Mini Symposium of Section of Medicinal and Pharmaceutical Chemistry, Zagreb, 2022.
  • A. Bosak, A. Matošević, A. Knežević, N. Maraković, Z. Kovarik. Biscarbamates as cholinesterase inhibitors in the treatment of Alzheimer’s disease, 14th International Meeting on Cholinesterases and 8th International Conference on Paraoxonases, Bologna, Italija, 2022.
  • I. Primožič, A. Matošević, A. Ramić, A. Mikelić, T. Hrenar, A. Bosak.Cinchona-alkaloid-derived compounds as selective inhibitors of butyrylcholinesterase. 14th International Meeting on Cholinesterases and 8th International Conference on Paraoxonases. Bologna, Italija, 2022.
  • A. Matošević, A. Bosak, A. Zandona, N. Maraković, Design, synthesis and biological evaluation of biscarbamates as potential selective butyrylcholinesterase inhibitors for the treatment of Alzheimer`s disease, Joint IUBMB/FEBS Advanced Lecture Course “Molecular targets for anti-aging interventions”, Spetses Island, Grčka, 2022.
  • A. Bosak, D. Opsenica, A. Matošević, K. Komatović, N. Terzić-Jovanović, S. Žunec, N. Maraković. Evaluation of 4-aminoquinolines as potential anticholinesterase agents in the treatment of Alzheimer`s disease, 17th International Symposium on Cholinergic Mechanisms (ISCM2022), Dubrovnik, 2022. (pozvano predavanje)
  • A. Matošević, A. Knežević, A. Zandona, N. Maraković, M. Katalinić, Z. Kovarik, A. Bosak. Synthesis and biological evaluation of heterocyclic meta-biscarbamates, 17th International Symposium on Cholinergic Mechanisms (ISCM2022), Dubrovnik, 2022.
  • D. Opsenica, A.Bosak, A. Matošević, K. Komatović, N. Maraković. 4-aminoquinolines, a privileged pharmacophore – from antimalarials to inhibition of cholinesterase, The 27th Croatian Meeting of Chemists and Chemical Engineers (27HSKIKI), Veli Lošinj, 2021.
  • A. Matošević, Dizajn, sinteza i biološka evaluacija biskarbamata, Hotel Academia, Zagreb, 2021.
  • A. Bosak, Razvoj lijekova za tretman neurodegegnarativnih bolesti, Županijsko stručno vijeće učitelja i nastavnika biologije Krapinsko-zagorske županije, 2021. (pozvano predavanje)
  • A. Matošević, A. Bosak. Design, synthesis and biological evaluation of compounds as active drugs in the central and peripheral nervous system, 5. Simpozija studenata doktorskih studija PMF-a, Zagreb, 2021.
Posterska priopćenja
  • M. Bartolić, D. Gašo Sokač, V. Bušić, A. Ramić, I. Primožič, A. Bosak. Comparison of structurally different ligands’ ability to prevent amyloid formation in Alzheimer’s disease. FEBS3+ Meeting Exploring Molecular Frontiers. Pula, 2024.
  • A. Bosak, A. Matošević, I. Primožič. Carbamates – A privileged pharmacophore in the design of potent cholinesterase inhibitors for treating alzheimer’s disease. FEBS3+ Meeting Exploring Molecular Frontiers. Pula, 2024.
  • A. Matošević, N. Maraković, Z. Kovarik, A. Bosak. BChE polymorphism effect on the efficiency of 5-(2-amino-1-hydroxyethyl) phenol carbamates as potential new drugs for advanced Alzheimer`s disease treatment. FEBS3+ Meeting Exploring Molecular Frontiers. Pula, 2024.
  • A. Matošević, A. Bosak. Synthesis and biological evaluation of carbamate derivatives of 3-(2-amino-1-hydroxyethyl) phenol as potential drugs for the treatment of Alzheimer`s disease. 11th EFMC Young Medicinal Chemists’ Symposium & The XXVIII EFMC International Symposium on Medicinal Chemistry, Rim, Italija, 2024.
  • M. Bartolić, A. Bosak. Prospect for development of Alzheimer’s disease drugs based on 4-aminoquinoline scaffold. The XXVIII EFMC International Symposium on Medicinal Chemistry, Rim, Italija, 2024.
  • M. Bartolić, Alma Ramić, Tomica Hrenar, Ines Primožič, Anita Bosak. Quinuclidinium oximes as cholinesterases’ and amyloid formation inhibitors. EMBO Workshop: Molecular Neurobiology 2024, Heraklion, Grčka, 2024.
  • M. Bartolić, D. Gašo-Sokač, V. Bušić, A. Ramić, I. Primožič, A Bosak, Amyloid-targeting approach for treatment of Alzheimer’s disease: biological evaluation of different structural scaffolds. 8th Faculty of Science PhD Student Symposium, Zagreb, 2024.
  • M. Bartolić, A. Bosak. Small Molecules, Big Dreams: In Search of Multi-Target Directed Ligands for the Treatment of Alzheimer’s Disease. 9th Conference of Young Chemists of Serbia, Novi Sad, Srbija, 2023.
  • A. Matošević, A. Bosak. Design, synthesis and biological evaluation of carbamates as cholinesterases inhibitors in the treatment of Alzheimer`s disease. 9th Conference of Young Chemists of Serbia. Novi Sad, Srbija, 2023.
  • M. Bartolić, P. Šušak, M. Arežina, M. Laučan, A. Ramić, T. Hrenar, I. Primožič, A. Bosak. Quinuclidinium based O-alkyl oximes as potential anticholinesterase agents in symptomatic treatment of Alzheimer’s disease. 10th EFMC Young Medicinal Chemists’ Symposium & IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry. Zagreb, 2023.
  • I. Novaković, A. Matošević, V. Milovanović, M. Bartolić, D. Opsenica, D. Sladić, A. Bosak. 1,4-benzoquinones as potent agents for Alzheimer`s disease treatment. IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry. Zagreb, 2023.
  • A. Bosak, A. Matošević, D.M. Opsenica, N. Maraković, A. Zandona, S. Žunec, M. Bartolić, S. Šegan. N-octylamino derivatives of 4-aminoquinoline as possible multifuctional agents for Alzheimer`s disease treatment. IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry. Zagreb, 2023.
  • A. Matošević, A. Bosak, A. Zandona, N. Maraković. Carbamates as potential new drugs in the treatment of Alzheimer`s disease. IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry &10th EFMC Young Medicinal Chemist`s Symposium. Zagreb, 2023.
  • M. Bartolić, A. Matošević, M. Spasić, D. Opsenica, A. Bosak. Evaluation of 4-aminoquinolines as potential MTDL ligands for the treatment of Alzheimer`s disease, Joint IUBMB/FEBS Advanced Lecture Course “Molecular targets for anti-aging interventions” Spetses Island, Grčka, 2022.
  • A. Matošević, A. Knežević, A. Zandona, N. Maraković, Z. Kovarik, A. Bosak. Design, synthesis and biological evaluation of biscarbamates as potentialselective butyrylcholinesterase inhibitors for the treatment of Alzheimer`s disease, Joint IUBMB/FEBS Advanced Lecture Course “Molecular targets for anti-aging interventions”, Spetses Island, Grčka, 2022.
  • K. Komatović, A. Matošević, M. Spasić, N. Maraković, A. Bosak, D. Opsenica. Synthesis and biological evaluation of 4-amino-7- chloroquinolines as novel reversible inhibitors of human cholinesterases, Congress of the Croatian Society of Biochemistry and Molecular Biology HDBMB22: From Science to Knowledge, Brela, Hrvatska, 2022.
  • M. Bartolić, A. Matošević, V. Bušić, D. Gašo Sokač, A. Bosak. Evaluation of hydrazone-based compounds as potential drugs for treatment of Alzheimer’s disease, European School of Medicinal Chemistry- 41st Advanced Course of Medicinal Chemistry and “E. Duranti” Seminar for PhD Students, Urbino, Italija, 2022.
  • A. Matošević, A. Knežević, N. Maraković, Z. Kovarik, A. Bosak. Design, synthesis and biological evaluation of cyclic biscarbamates as selective butyrylcholinesterase inhibitors in the treatment of Alzheimer`s disease, European School of Medicinal Chemistry- 41st Advanced Course of Medicinal Chemistry and “E. Duranti” Seminar for PhD Students, Urbino, Italija, 2022.
  • M. Bartolić, A. Matošević, V. Bušić, D. Gašo-Sokač, A. Bosak. Hydrazone-based compounds evaluated as inhibitors of human cholinesterases, 17th International Symposium on Cholinergic Mechanisms (ISCM2022), 17th International Symposium on Cholinergic Mechanisms (ISCM2022), Dubrovnik, 2022.
  • A. Matošević, A. Knežević, A. Zandona, N. Maraković, M. Katalinić, Z. Kovarik, A. Bosak. Synthesis and biological evaluation of heterocyclic meta-biscarbamates, 17th International Symposium on Cholinergic Mechanisms (ISCM2022), Dubrovnik, 2022.
  • D. Opsenica, A. Bosak, A. Matošević, K. Komatović, N. Maraković. 4-aminoquinolines, a privileged pharmacophore- from antimalarials to inhibition of cholinesterase. Book of Abstracts of the 27th Croatian Meeting of Chemists and Chemical Engineers (27HSKIKI). Veli Lošinj, Hrvatska. 2021.
  • A. Matošević, A. Bosak. Application of NMR for monitoring the synthetic route and characterization of bisacrbamates. The Adriatic NMR Conference 2021. Primošten, Hrvatska. 2021.
  • K. Komatović, A. Matošević, N. Terzić- Jovanović, A. Bosak, D. Opsenica. Adamantane based derivatives as reversible inhibitors of human AChE and BChE. FEBS Open Bio 11 (Suppl. 1); 45th FEBS Congress, Molecules of Life: Towards New Horizons. Ljubljana, Slovenija. 2021.
  • A. Bosak, A. Matošević, A. Zandona, G. Šinko, K. Komatović, D. Opsenica. New 4-aminoquinoline-based cholinesterase inhibitors. FEBS Open Bio (Suppl. 1); 45th FEBS Congress, Molecules of Life: Towards New Horizons. Ljubljana, Slovenija. 2021.
  • A. Matošević, A. Knežević, A. Bosak. Heterocyclic carbamates as potential drugs for the treatment of the neurodegenrative diseases. The 29th European Colloquium on Heterocyclic Chemistry. Rouen, Francuska, 2021.
  • A. Matošević, A. Bosak. Design, synthesis and biological evaluation of compounds as active drugs in the central and peripheral nervous system. 5. Simpozij studenata doktorskih studija PMF-a, Zagreb, Hrvatska, 2021.
Novi projekti
  • A. Matošević Potpora Zaklade Hrvatske akademije znanosti i umjetnosti za projekt „Sinteza i biološka evaluacija karbamata kao potencijalnih inhibitora kolinesteraza u tretmanu Alzheimerove bolesti“
Nagrade/priznanja/stipendije
  • M. Bartolić. Godišnja nagrada Hrvatskog kemijskog društva za mlade medicinske i farmaceutske kemičare za 2023.
  • M. Bartolić. EMBO Mol Neuro 2024 – travel grant za sudjelovanje na EMBO Workshop Molecular neurobiology, 2024, Heraklion, Grčka
  • A. Matošević. Stipendija European Federation for Medicinal Chemistry za sudjelovanje na XXVIII EFMC International Symposium on Medicinal Chemistry & EFMC- Young Medicinal Chemists’ Symposium, 2024, Rim, Italija
  • M. Bartolić. Stipendija Hrvatskog kemijskog društva za sudjelovanje na XXVIII EFMC International Symposium on Medicinal Chemistry, 2024, Rim, Italija
  • A. Matošević. Stipendija Hrvatskog društva za biokemiju i molekularnu biologiju za sudjelovanje na FEBS3+ Meeting: Exploring molecular Frontiers, 2024. Pula, Hrvatska
  • A. Matošević. Stipendija Hrvatskog kemijskog društva za sudjelovanje na Xth EFMC Young Chemist`s Symposium, 2023, Zagreb, Hrvatska
  • A. Matošević. FEBS Travel Grant za sudjelovanje na Joint IUBMB/FEBS Advanced Lecture Course Molecular Targets for Anti-aging Interventions, 2022, Spetses Island, Grčka
  • A. Matošević. The Young ISN Neurochemistry Award za sudjelovanje na 17th International Symposium on Cholinergic Mechanisms, 2022, Dubrovnik, Hrvatska
Nastavna djelatnost (diplomski radovi, stručne prakse)
  • 2024. Diplomski rad studentice Kemije na Prirodoslovno- matematičkom fakultetu u Zagrebu Petre Šušak “Inhibicija humanih kolinesteraza O-alkiloksimima”- mentorica dr. sc. A. Bosak, neposredna voditeljica M. Bartolić, mag. chem.
  • 2023. Diplomski rad studentice Kemije na Prirodoslovno- matematičkom fakultetu u Zagrebu Aleksandrine Vodolšak “Sinteza i biološka evaluacija heterocikličkih karbamata kao inhibitora humanih kolinesterazaima”- mentorica dr. sc. A. Bosak, neposredna voditeljica dr. sc. A. Matošević
  • 2023. Stručna praksa studentice Kemije na Prirodoslovno- matematičkom fakultetu u Zagrebu Petre Šušak“- mentorica dr. sc. A. Matošević
  • 2021. Stručna praksa studentice Kemije na Prirodoslovno- matematičkom fakultetu u Zagrebu Aleksandrina Vodolšak “- mentorica dr. sc. A. Matošević
  • 2021. Sudjelovanje u održavanju kolegija Praktikum biokemije studentima III. godine Prediplomskog studija Kemije na Prirodoslovno-matematičkom fakultetu u Zagrebu- dr. sc. A. Matošević
Popularizacija znanosti i projekta
  • M. Bartolić. Je li znanstveni rad težak? Radionica, IMI, Zagreb, 22.3.2024. Učenici 8. r. (na slici lijevo)
  • A. Matošević. Što i kako radi organski sintetičar? Radionica, IMI, Zagreb, 22.3.2024. Učenici 8. r. (na slici desno)

Radionice/tečajevi/webinari
  • M. Bartolić; ERASMUS+ ToxLearn4EU Summer School, Hasselt, Belgija, 29.6. – 6.7.2024.
  • M. Bartolić; EMBO Workshop: Molecular Neurobiology 2024, Heraklion, Grčka, 13. – 17.5.2024.
  • M. Bartolić, A. Matošević; EU-OPENSCREEN Autumn training school 2023 on topics related to Chemical biology & Drug discovery, 20.-22.11.2023. (on-line)
  • M. Bartolić, A. Matošević; International training on cell culture cultivation and cell-assay performance, 1.-12.10.2023., Zagreb, Hrvatska
  • M. Bartolić, A. Bosak, A. Matošević; Shimadzu radionica “Nexera LC-40 with PDA detector- Theory, LabSolution software, maintenance, troubleshooting”, 15.-17.2.2023., Zagreb, Hrvatska
  • A. Bosak, A. Matošević; FDA Clinical Investigator Training Course, U. S. Food & Drug Administration, 7.-8.12.2022. (on-line)
  • M. Bartolić, A. Bosak, A. Matošević; 1st Workshop in Mass Spectrometry in Life Sciences, Prirodoslovno-matematički fakultet, Zagreb, 24.-26.11.2022.
  • M. Bartolić, A. Matošević; Joint IUBMB/FEBS Advanced Lecture Course “Molecular targets for anti-aging interventions”, Spetses Island, Grčka, 26.9.-1.10.2022.
  • M. Bartolić, A. Matošević; European School of Medicinal Chemistry- 41st Advanced Course of Medicinal Chemistry and “E. Duranti” Seminar for PhD Students, Urbino, Italija, 3.-7.7. 2022.
  • M. Bartolić, A. Matošević; Uvod u molekulsko modeliranje, Institut “Ruđer Bošković”, Zagreb, 2.-6.12.2021.
  • M. Bartolić; Education workshop – Better skills for better jobs: excellent lab book for an excellent career, 11.-12.11.2021. (on-line)
  • A. Bosak; seminar Uvod u upravljanje projektima, Bicro Biocentar, Zagreb, 26. 10. 2021.
  • M. Bartolić, A. Matošević; Praktična radionica Tekućinska kromatografija i spektrometrija masa, BICRO BIOCentar d.o.o., Zagreb 12.-13.10.2021.
  • A. Matošević; SPICA Virtual Session The importance of Chromatography in the Development of Vaccines, 14.10.2021. (on-line)
  • A. Matošević; 2nd Symeres Precision Chemistry Conference on Tools for Molecular Recognition and Diagnostics, 12.-13.10.2021. (on-line)
  • A. Matošević; Reaxys webinar, Hrvatsko kemijsko društvo i Elsevier, 23.04.2021.
  • A. Matošević; webinar Intact and peptide level characterization of nanobodies by high resolution HPLC-MS/MS, 12.2.2021.
Projekt u slikama…

A. Bosak, 15th International Meeting on Cholinesterases, 9th International Meeting on Paraoxonases (ChE-PON 2024). Brdo pri Kranju, Slovenija, 2024.

M. Bartolić, 11th EFMC Young Medicinal Chemists’ Symposium & The XXVIII EFMC International Symposium on Medicinal Chemistry, Rim, Italija, 2024.

A. Matošević, 9th Conference of Young Chemists of Serbia, Novi Sad, Srbija, 2023

Matošević, 6th Mini Symposium of Section of Medicinal and Pharmaceutical Chemistry, Zagreb, Hrvatska, 2022.

A. Matošević (lijevo) i M. Bartolić (desno), Joint IUBMB/FEBS Advanced Lecture Course “Molecular targets for anti-aging interventions”, Spetses Island, Grčka, 2022.

M. Bartolić (lijevo) i A. Matošević (desno), European School of Medicinal Chemistry- 41st Advanced Course of Medicinal Chemistry and “E. Duranti” Seminar for PhD Students , Urbino, Italija, 2022.

A. Bosak, A.Matošević i M. Bartolić (s lijeva) 17th International Symposium on Cholinergic Mechanism, Dubrovnik

A. Matošević; 5. Simpozij studenata doktorskih studija PMF-a, Zagreb, Hrvatska, 2021.