MatoÅ”eviÄ, A KneževiÄ, A. Zandona, N. MarakoviÄ, Z. Kovarik, A. Bosak, Design, synthesis and biological evaluation of biscarbamates as potential selective butyrylcholinesterase inhibitors for the treatment of Alzheimerās disease, Pharmaceuticals 2022, 15, 1220. doi:10.3390/ph15101220 (IF (2021) = 5,21; Q1)
KomatoviÄ, A. MatoÅ”eviÄ, N. TerziÄ-JovanoviÄ, S. Žunec, S. Å egan, M. ZlatoviÄ, N. MarakoviÄ, A. Bosak, D. Opsenica, 4-aminoquinoline-based adamantanes as potential anticholinesterase agents in symptomatic treatment of Alzheimerās disease. Pharmaceutics 2022, 14, 1305. doi:10.3390/pharmaceutics14061305 (IF= 6,52 (2021); Q1)
MatoÅ”eviÄ, A. Radman Kastelic, A. MikeliÄ, A. Zandona, M. KataliniÄ, I. PrimožiÄ, A. Bosak, T. Hrenar, Quinuclidine-based carbamates as potential CNS active compounds, Pharmaceutics, 13 (2021), 3; 420, 15 doi:10.3390/pharmaceutics13030420 (IF (2020) =6,52; Q1).
Participation at scientific meetings
BartoliÄ, Evaluation of 4-aminoquinolines as potential MTDL ligands for the treatment of Alzheimer`s disease, Joint IUBMB/FEBS Advanced Lecture Course “Molecular targets for anti-aging interventions”, Spetses Island, GrÄka, 26.9.-1.10.2022.
MatoÅ”eviÄ, Design, synthesis and biological evaluation of biscarbamates as potentialselective butyrylcholinesterase inhibitors for the treatment of Alzheimer`s disease, Joint IUBMB/FEBS Advanced Lecture Course “Molecular targets for anti-aging interventions”, Spetses Island, GrÄka, 26.9.-1.10.2022.
KomatoviÄ, Synthesis and biological evaluation of 4-amino-7- chloroquinolines as novel reversible inhibitors of human cholinesterases, Congress of the Croatian Society of Biochemistry and Molecular Biology HDBMB22: From Science to Knowledge , Brela, Hrvatska 28.9.-1.10.2022.
Bosak, Biscarbamates as cholinesterase inhibitors in the treatment of Alzheimerās disease, 14th International Meeting on Cholinesterases and 8th International Conference on Paraoxonases, Bologna, Italija, 18.-21.9.2022.
BartoliÄ, Evaluation of hydrazone-based compounds as potential drugs for treatment of Alzheimerās disease, European School of Medicinal Chemistry- 41st Advanced Course of Medicinal Chemistry and āE. Durantiā Seminar for PhD Students , Urbino, Italija, 3.-7.7. 2022.
MatoÅ”eviÄ, Design, synthesis and biological evaluation of cyclic biscarbamates as selective butyrylcholinesterase inhibitors in the treatment of Alzheimer`s disease, European School of Medicinal Chemistry- 41st Advanced Course of Medicinal Chemistry and āE. Durantiā Seminar for PhD Students , Urbino, Italija, 3.-7.7. 2022.
BartoliÄ, Hydrazone-based compounds evaluated as inhibitors of human cholinesterases, 17th International Symposium on Cholinergic Mechanisms (ISCM2022), 17th International Symposium on Cholinergic Mechanisms (ISCM2022), Dubrovnik, 8.-12.5.2022.
Bosak, Evaluation of 4-aminoquinolines as potential anticholinesterase agents in the treatment of Alzheimer`s disease, 17th International Symposium on Cholinergic Mechanisms (ISCM2022), Dubrovnik, 8.-12.5.2022.
MatoÅ”eviÄ, Synthesis and biological evaluation of heterocyclic meta-biscarbamates, 17th International Symposium on Cholinergic Mechanisms (ISCM2022), Dubrovnik, 8.-12.5.2022.
Opsenica, A. Bosak, A. MatoÅ”eviÄ, K. KomatoviÄ, N. MarakoviÄ. 4-aminoquinolines, a privileged pharmacophore- from antimalarials to inhibition of cholinesterase. Book of Abstracts of the 27th Croatian Meeting of Chemists and Chemical Engineers (27HSKIKI). Veli LoÅ”inj, Hrvatska. 5.-8.10.2021. (abstract)
MatoÅ”eviÄ, A. Bosak. Application of NMR for monitoring the synthetic route and characterization of bisacrbamates. Book of abstracts of the Adriatic NMR Conference 2021. PrimoÅ”ten, Hrvatska. 13.-15.9.2021.; str. 46. (poster, abstract)
KomatoviÄ, A. MatoÅ”eviÄ, N. TerziÄ- JovanoviÄ, A. Bosak, D. Opsenica. Adamantane based derivatives as reversible inhibitors of human AChE and BChE. FEBS Open Bio 11 (Suppl. 1); 45th FEBS Congress, Molecules of Life: Towards New Horizons. Ljubljana, Slovenija. 3.-8. 7. 2021.; str. 213. (poster)
Bosak, A. MatoÅ”eviÄ, A. Zandona, G. Å inko, K. KomatoviÄ, D. Opsenica. New 4-aminoquinoline-based cholinesterase inhibitors. FEBS Open Bio (Suppl. 1); 45th FEBS Congress, Molecules of Life: Towards New Horizons. Ljubljana, Slovenija. 3.ā8. 7. 2021.; str. 310.-311. (poster, abstract)
MatoÅ”eviÄ, A. KneževiÄ, A. Bosak. Heterocyclic carbamates as potential drugs for the treatment of the neurodegenrative diseases. Book of abstracts of 29th European Colloquium on Heterocyclic Chemistry. Rouen, Francuska, 26-28. 4. 2021.; str. 143. (poster, sažetak)
MatoÅ”eviÄ, A. Bosak. Design, synthesis and biological evaluation of compounds as active drugs in the central and peripheral nervous system. Knjiga sažetaka 5. Simpozija studenata doktorskih studija PMF-a, Zagreb, Hrvatska, 24-25. 4. 2021.; str. 146. (poster, abstract)
Bosak, Development of bioactive molecules for treatment of Alzheimerās diseases, Symposium āCell-BasedResearch inToxicologyandDrug Designā, Zagreb, 26.1.2023.
MatoÅ”eviÄ, Design and synthesis of selective butyrylcholinesterase inhibitors as multi- target directed ligands in the treatment of Alzheimerās disease, 6th Mini Symposium of Section of Medicinal and Pharmaceutical Chemistry, Zagreb, 22.11.2022.
Bosak, Biscarbamates as cholinesterase inhibitors in the treatment of Alzheimerās disease, 14th International Meeting on Cholinesterases and 8th International Conference on Paraoxonases, Bologna, Italija, 18.-21.9.2022.
MatoÅ”eviÄ, Design, synthesis and biological evaluation of biscarbamates as potential selective butyrylcholinesterase inhibitors for the treatment of Alzheimer`s disease, Joint IUBMB/FEBS Advanced Lecture Course “Molecular targets for anti-aging interventions”, Spetses Island, GrÄka, 26.9.-1.10.2022.
Bosak, Evaluation of 4-aminoquinolines as potential anticholinesterase agents in the treatment of Alzheimer`s disease, 17th International Symposium on Cholinergic Mechanisms (ISCM2022), Dubrovnik, 8.-12.5.2022.
MatoÅ”eviÄ, Synthesis and biological evaluation of heterocyclic meta-biscarbamates, 17th International Symposium on Cholinergic Mechanisms (ISCM2022), Dubrovnik, 8.-12.5.2022.
Opsenica, 4-aminoquinolines, a privileged pharmacophore – from antimalarials to inhibition of cholinesterase, The 27th Croatian Meeting of Chemists and Chemical Engineers (27HSKIKI), Veli LoÅ”inj, 5.-8.10.2021.
MatoÅ”eviÄ, Design, synthesis and biological evaluation of biscarbamates, Hotel Academia, Zagreb. 2.11.2021.
Bosak, Razvoj lijekova za tretman neurodegegnarativnih bolesti. Županijsko struÄno vijeÄe uÄitelja I nastavnika biologije Krapinsko-zagorske županije,1. 7. 2021.
MatoÅ”eviÄ, Design, synthesis and biological evaluation of compounds as active drugs in the central and peripheral nervous system, 5th Symposium of PhD students, Faculty of science, Zagreb-a 24. 4. 2021.
Workshops/courses/webinars
Bosak, A. MatoÅ”eviÄ; FDA Clinical Investigator Training Course, U. S. Food & Drug Administration, 7.-8.12.2022. (on-line)
BartoliÄ, A. Bosak, A. MatoÅ”eviÄ; 1st Workshop in Mass Spectiometry in Life Sciences, Prirodoslovno-matematiÄki fakultet, Zagreb, 24.-26.11.2022.
BartoliÄ, A. MatoÅ”eviÄ; Uvod u molekulsko modeliranje, Institut āRuÄer BoÅ”koviÄā, Zagreb, 2.-6.12.2021.
BartoliÄ, Education workshop – Better skills for better jobs: excellent lab book for an excellent career, 11.-12.11.2021. (on-line)
Bosak; seminar Uvod u upravljanje projektima, Bicro Biocentar, Zagreb, 26. 10. 2021.
BartoliÄ, A. MatoÅ”eviÄ; Practical workshop ā TekuÄinska kromatografija i spektrometrija masaā, BICRO BIOCentar d.o.o., Zagreb 12.-13.10.2021.
MatoÅ”eviÄ SPICA Virtual Session The importance of Chromatography in the Development of Vaccines, 14.10.2021. (on-line)
MatoÅ”eviÄ; 2nd Symeres Precision Chemistry Conference on Tools for Molecular Recognition and Diagnostics, 12.-13.10.2021. (on-line)
MatoÅ”eviÄ; Reaxys webinar, Hrvatsko kemijsko druÅ”tvo i Elsevier, 23.04.2021.
A. MatoÅ”eviÄ, webinar, Intact and peptide level characterization of nanobodies by high resolution HPLC-MS/MS, 12.2.2021.
Valentina BuÅ”iÄ, Marija BartoliÄ, Anita Bosak, Ana MatoÅ”eviÄ, Dajana GaÅ”o SokaÄ (from the left) Symposium āCell-Based Research inToxicology and Drug Designā, Zagreb, 26 Jan 2023
Ana MatoÅ”eviÄ, 6th Mini Symposium of Section of Medicinal and Pharmaceutical Chemistry, Zagreb
Ana MatoÅ”eviÄ (left) and M. BartoliÄ (right), Joint IUBMB/FEBS Advanced Lecture Course “Molecular targets for anti-aging interventions”, Spetses Island, GrÄka
Marija BartoliÄ (left) and Ana MatoÅ”eviÄ (right), European School of Medicinal Chemistry – 41st Advanced Course of Medicinal Chemistry and āE. Durantiā Seminar for PhD Students , Urbino, Italija
Anita Bosak, 17th International Symposium on Cholinergic Mechanisms (ISCM2022), Dubrovnik
Ana MatoÅ”eviÄ, 17th International Symposium on Cholinergic Mechanisms (ISCM2022), Dubrovnik
Marija BartoliÄ, 17th International Symposium on Cholinergic Mechanisms (ISCM2022), Dubrovnik
Ana MatoÅ”eviÄ; predavanje na 5. Simpoziju studenata doktorskih studija PMF-a, Zagreb, Hrvatska
Ana MatoÅ”eviÄ; postersko priopÄenje na Adriatic NMR Conference 2021. PrimoÅ”ten, Hrvatska
Participants (IMI): Gordana Pehnec, Marko GeriÄ, Ivana JakovljeviÄ, Silvije Davila, Iva Å imiÄ, Mirta MiliÄ, Vilena KaÅ”uba, Katarina MatkoviÄ, Ivana Vrhovac MaduniÄ, Dean Karaica, Maja NikoliÄ, Luka Kazensky, Vedran Micek, Davorka Breljak, Tajana Horvat i Marija Jelena LovriÄ
Programme: HORIZON
Call: HORIZON-HLTH-2021-ENVHLTH-02
Duration: 01.12.2022. ā 30.11.2026.
Abstract: Indoor air pollution, an emerging threat recognized by European society, is claiming millions of lives annually. In the heat of current COVID-19 pandemic, elevated exposure to indoor air pollutants due to increased time spent indoors further faces a significant increase in negative effect on both physical and mental health and well-being not only in Europe, but also worldwide. When it comes to indoor air quality itself, serious knowledge gaps remain in understanding complex nature of indoor-outdoor pollution relationships, pollution sources and exposure pathways, health effects of emerging pollutants, ventilation of indoor spaces on wide spatial and long temporal scales. This is mainly because air quality monitoring in European Union (EU) is primarily focused on outdoor air quality, which paradoxically is a result of regulatory target compliances, which is lacking for indoor environments. To increase the resilience of EU for emerging threats of indoor air pollution and to promote living and working in healthy environments, project EDIAQI aims at conducting characterization of sources and routes of exposure and dispersion of chemical, biological, and emerging indoor air pollution in multiple cities in EU. Quantification of the main properties of pollutants and processes that governs its fate in indoor environments will be investigated on two levels: a) the-state-of-the-art, small-scale, high-intensity scientific focus measurement campaigns; and b) long-term, large-scale monitoring of target indoor air pollutants. The chosen project strategy for developing, characterization, and deployment of cost-effective/user-friendly monitoring solutions, together with the-state-of-the-art scientific instrumentation will allow to create new knowledge on sources, routes of exposure, and body burdens of indoor multipollutant.
IMI Participants: Mirta MiliÄ, Marko GeriÄ, Goran Gajski
Programme: Erasmus+
Action Type:Ā KA220-HED – Cooperation partnerships in higher education
Field: Higher Education
Duration: 31.1.2022. – 31.1.2025.
Objectives: The Erasmus ToxLearn4EU project was built by a consortium of 7 HEIs and 3 research centres and laboratory. It aims to modernize of Toxicology and Ecotoxicology teaching in Europe and has several objectives and target audiences:
develop and use innovative and free educational resourcesĀ interactive courses, online PBL) in order to develop high quality digital education
provide innovative content on current hot topics in the field of Toxicology/Ecotoxicology to fit with recent evolution of European Policy (Action Plan: ‘Towards Zero Pollution’) and with job market needs
stimulate interest of students for those fields and limit school dropout by putting students back at the centre of teaching through the use of active pedagogies adapted to digital practice to recreate interactions between students, between students and teachers, and by stimulating their motivation through playful approaches.
The project meets the needs of:
students by stimulating their interest and limiting school dropout, putting them back at the centre of teaching through the use of active pedagogies adapted to digital practice to recreate interactions between students, between students and teachers, and by stimulating their motivation through playful approaches.
teachers by proposing stimulating online courses which can be integrated in their own courses, or by motivating them to design and create their own new innovative courses.
partners by modernizing part of their curricula.
stakeholders of toxicology and ecotoxicology by developing student and lifelong learner competencies adapted to job market and up-to-date to recent changes at the European Level (Green Deal)
European Commission by modifying curricula and developing courses adapted to the Green Deal. This will contribute to reach the ambitious objectives of EU Action Plan Towards Zero Pollution.
Croatian-German Scientific Research Project funded by the Ministry of Science and Education of the Republic of Croatia and the German Academic Exchange Service (DAAD)
Project leaders:
Ivana Vrhovac MaduniÄ (Croatian leader), IMROH
Mladen V. Tzvetkov (German leader), University of Medicine, Greifswald
Project participants: Maja KataliniÄ, Josip MaduniÄ, Zrinka Kovarik, Antonio Zandona, Tena Äadež, Marleen Meyer, Sarah RÅmer
Project participants: Maja KataliniÄ, Josip MaduniÄ, Dean Karaica, Antonio Zandona, Ana-Marija LuliÄ
Croatian Academy of Sciences and Arts
Duration: 2021-2022
Summary
The aim of this project is to determine whether newly synthesized oxime compounds inhibit glucose uptake and thus the growth of human prostate cancer cells and as such can be considered as candidates for antitumor drugs. Most of the newly synthesized oximes that will be examined are either constantly positively charged quaternary amines, or contain amino groups that could be strongly protonated under physiological conditions.
Sažetak: The network aims at fueling urgently needed collaborations in the field of correlated multimodal imaging (CMI), promoting and disseminating its benefits through showcase pipelines, and paving the way for its technological advancement and implementation as a versatile tool in biological and preclinical research. CMI combines two or more imaging modalities to gather information about the same specimen. It creates a composite view of the sample with multidimensional information about its macro-, meso- and microscopic structure, dynamics, function and chemical composition. Since no single imaging technique can reveal all these details, CMI is the only way to understand biomedical processes and diseases mechanistically and holistically. CMI relies on the joint multidisciplinary expertise from biologists, physicists, chemists, clinicians and computer scientists, and depends on coordinated activities and knowledge transfer between academia and industry, and instrument developers and users. Due to its inherently multidisciplinary and cross-functional nature, an interdisciplinary network such as this Action is indispensable for the success of CMI. Nevertheless, there is currently no European network in the field. Existing scattered efforts focus on correlated light and electron microscopy or (pre)clinical hybrid imaging. This Action will consolidate these efforts, establish commonly-accepted protocols and quality standards for existing CMI approaches, identify and showcase novel CMI pipelines, bridge the gap between preclinical and biological imaging, and foster correlation software through networking, workshops and open databases. The network will raise awareness for CMI, train researchers in multimodal approaches, and work towards a scientific mindset that is enthusiastic about interdisciplinary imaging approaches in life sciences.
Regardless of the fact that polyaromatic hydrocarbons (PAHs) and persistent organic pollutants (POPs) have been explored widely over the past several decades, the determination of their environmental distribution and impact on human health are intensively present in scientific research around the world. PAHs are a complex group of pollutants formed by the incomplete combustion of organic material. Many countries around the world, including Croatia, monitor ambient air quality through their monitoring networks, used for implementing emission reduction measures. POPs are compounds characterised by persistence, bioaccumulation, toxicity, and long range transport via air. In order to prevent or reduce the release of POPs into the environment, the Stockholm Convention on Persistent Organic Pollutants was introduced. The Convention entered into force in 2004, and in 2006 the Parliament of the Republic of Croatia declared the Act on the Ratification of the Stockholm Convention on Persistent Organic Pollutants (OG-11/2006). Among other things, the Convention prescribes the monitoring of POPs in the biotic and abiotic parts of the environment.
Cooperation with AQUATIKA has begun on this project, which adds to the long-term collaborations of researchers from Croatia (Department of Health Studies, University of Zadar; IMROH) and Serbia (Institute of Physics Belgrade; University of Belgrade, Faculty of Chemistry, University of Belgrade; VinÄa Institute of Nuclear Science).
Foundation of the Croatian Academy for Sciences and Arts
Duration: 2020 ā 2021
Summary
The aim of this project is to optimize the conditions for microwave-assisted extraction (MAE) of 7 polybrominated diphenyl ether (PBDE) congeners from human milk samples by selecting a suitable solvent mixture, temperature, and the required time for extraction. Particular emphasis is placed on the impact of human milk sample pretreatment on the MAE efficiency. This will be the first application of MAE technique for extraction of PBDEs from human milk samples in the world, and the preliminary data on PBDEs mass fractions in human milk from Croatia, which will enable assessment of Croatian population exposure to PBDEs, and based on which it will be possible to assess the potential risk to human health.
