- Scientific research in the fields of experimental biomedicine and (patho) physiology – Membrane transporters of sodium and glucose (SGLT1, SGLT2, SGLT3), organic anion (NaDC3, OAT1-3, SAT-1, CFEX)) and water channel (AQP) in different organs of experimental animals (mice, rats) and humans – studying sex and species differences in the expression, their regulation by sex hormones at the level of mRNA and protein.
- Studying mechanism of aging ie. impact of aging on the activity/expression of various membrane transporters in the liver and kidneys. The emphasis is on insufficiently explored membrane transporters of organic and inorganic substances that play a key role in the interaction of drugs and drug resistance.
SPECIFIC RESEARCH INTERESTS
- Discovering new cellular localizations of membrane transporters of sodium and glucose (SGLT1, SGLT2, SGLT3) and understanding their regulation in type 2 diabetes and other diseases (eg, cancer).
- Studying the effects of a new generation of anti-diabetic drugs (SGLT inhibitors) on the expression and function of SGLT1, SGLT2 and SGLT3 in different organs/tissue
OTHER SCIENTIFIC INTERESTS
- Oncology, mutagenesis and carcinogenesis
- The effects of natural and synthetic compounds on tumor and non-tumor cells and organs
- Methods of molecular and cell biology: extraction of DNA and RNA, RT-PCR, standard PCR, real-time PCR, SDS-PAGE, Western blotting, cell culture, light and fluorescent microscopy (immunohistochemistry)
- Hermann Koepsell, PhD, Department of Anatomy and Cell Biology at the University of Würzburg (Germany)
- Mirko Hadžija, PhD and Marijana Popovic-Hadžija, PhD, Ruder Boskovic Institute in Zagreb, Croatia