Anita Bosak

Biochemistry and Organic Analytical Chemistry Unit

PhD, MSc / Scientific Associate

Place and date of birth

Zagreb, January 1974

Education

  • 2005-2010 Faculty of Science, University of Zagreb. “Inhibition of cholinesterases by catechol and resorcinol derivatives” [Doctoral thesis]. Supervisor: Z. Kovarik.
  • 2000-2004 Faculty of Science, University of Zagreb. “Interaction of cholinesterases with enantiomers of quinuclidin-3-ol derivatives” [M. Sc. Thesis]. Supervisor: Vera Simeon.
  • 1992-1998 Faculty of Science, University of Zagreb; Diploma in Chemistry. “Michaelis constants and maximum reaction rates for the hydrolysis of phenylacetate by human serum arylesterases” [B.Sc. Thesis]. Supervisor: E. Reiner.

Work Experience

  • Since 1999 Institute for Medical Research and Occupational Health, Zagreb, Croatia

Fields of interest

biochemistry, enzyme kinetic, interaction of cholinesterases with reversible and progressive inhibitors, stereoselectivity of cholinesterases towards enantiomers of pharmacologically active compounds

Additional training

  • September 2003 “8th International Summer School on Biophysics, Supramolecular Structure and Function“, Rovinj, Croatia.
  • September 2006 “Molecular Design and Computer Assisted Combinatorial Chemistry“, ICS-UNIDO Trieste, Italy.
  • October 2007 Laboratory for Molecular Neurobiology, Medical Faculty, Ljubljana, Slovenia.
  • November 2011 “Biochemistry and Molecular Biology Education Workshop“, Ljubljana, Slovenia
  • September 2013 Institute of Biochemistry, Medical Faculty, University of Ljubljana, Slovenia
  • October 2014 “Scientific Publishing and Intellectual Property Protection in the Life Sciences”, Zagreb, Croatia
  • May 2015 Institute of Biochemistry, Medical Faculty, University of Ljubljana, Slovenia
  • October 2015 “The Application of the 3R Approach in Working with Laboratory Animals“, Zagreb, Croatia • December 2016 “Basics of Proteomics“, Zagreb, Croatia

Awards

  • 2009 Annual award for young scientist in 2008- The Croatian Society of Biochemistry and Molecular Biology
  • 2009 Annual award of the Institute for Medical Research and Occupational Health for young researchers in 2008
  • 2012 Annual award of the Institute for Medical Research and Occupational Health for the publication with the highest number of citations
  • 2013 Annual award of the Institute for Medical Research and Occupational Health for the scientific paper published in 2002. in a journal best rated according to JCR Science Edition

Select Publications

  1. P. Eyer, F. Worek, D. Kiderlen, G. Sinko, A. Stuglin, V. Simeon-Rudolf, E. Reiner, Molar absorption coefficients for the reduced Ellman reagent: reassessment, Analytical Biochemistry 312 (2003) 224–227.
  2. A. Bosak, I. Primožič, M. Oršulić, S. Tomić, V. Simeon-Rudolf, Enantiomers of quinuclidin-3-ol derivatives: Resolution and interactions with human cholinesterases, Croatica Chemica Acta 78 (2005) 121-128.
  3. I. Gazić, A. Bosak, G. Šinko, V. Vinković, Z. Kovarik, Preparative HPLC separation and stereoselective inhibition of human cholinesterases, Analytical and Bioanalytical Chemistry 385 (2006) 1513-1519.
  4. A. Bosak, I. Gazić, V. Vinković, Z. Kovarik, Stereoselective inhibition of cholinesterases by bambuterol enantiomers, Chemico-Biological Interactions 175 (2008) 192-195.
  5. A. Bosak, I. Gazić-Smilović, G. Šinko, V. Vinković, Z. Kovarik, Metaproterenol, Isoproterenol, and their bisdimethylcarbamate derivatives as human cholinesterase inhibitors, Journal of Medicinal Chemistry 55 (2012) 6716-6723.
  6. M. Katalinić, A. Bosak, Z. Kovarik, Flavonoids as inhibitors of human butyrylcholinesterase variants, Food Technology and Biotechnology 52(1) (2014) 64-67.

Memberships

  • The Croatian Biochemical Society
  • The Croatian Toxicological Society
  • The Croatian Society of Natural Sciences (treasurer since 2016)

List of publications