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Development of Bioactive Molecules for Neurodegenerative Diseases Treatment – BioMol4ND

PUBLICATIONS

Articles in journals
  1. MatoÅ”ević, A Knežević, A. Zandona, N. Maraković, Z. Kovarik, A. Bosak, Design, synthesis and biological evaluation of biscarbamates as potential selective butyrylcholinesterase inhibitors for the treatment of Alzheimerā€™s disease, Pharmaceuticals 2022, 15, 1220. doi:10.3390/ph15101220 (IF (2021) = 5,21; Q1)
  2. Komatović, A. MatoÅ”ević, N. Terzić-Jovanović, S. Žunec, S. Å egan, M. Zlatović, N. Maraković, A. Bosak, D. Opsenica, 4-aminoquinoline-based adamantanes as potential anticholinesterase agents in symptomatic treatment of Alzheimerā€™s disease. Pharmaceutics 2022, 14, 1305. doi:10.3390/pharmaceutics14061305 (IF= 6,52 (2021); Q1)
  3. MatoÅ”ević, A. Radman Kastelic, A. Mikelić, A. Zandona, M. Katalinić, I. Primožič, A. Bosak, T. Hrenar, Quinuclidine-based carbamates as potential CNS active compounds, Pharmaceutics, 13 (2021), 3; 420, 15 doi:10.3390/pharmaceutics13030420 (IF (2020) =6,52; Q1).
Participation at scientific meetings
  1. Bartolić, Evaluation of 4-aminoquinolines as potential MTDL ligands for the treatment of Alzheimer`s disease, Joint IUBMB/FEBS Advanced Lecture Course “Molecular targets for anti-aging interventions”, Spetses Island, Grčka, 26.9.-1.10.2022.
  2. MatoÅ”ević, Design, synthesis and biological evaluation of biscarbamates as potentialselective butyrylcholinesterase inhibitors for the treatment of Alzheimer`s disease, Joint IUBMB/FEBS Advanced Lecture Course “Molecular targets for anti-aging interventions”, Spetses Island, Grčka, 26.9.-1.10.2022.
  3. Komatović, Synthesis and biological evaluation of 4-amino-7- chloroquinolines as novel reversible inhibitors of human cholinesterases, Congress of the Croatian Society of Biochemistry and Molecular Biology HDBMB22: From Science to Knowledge , Brela, Hrvatska 28.9.-1.10.2022.
  4. Bosak, Biscarbamates as cholinesterase inhibitors in the treatment of Alzheimerā€™s disease, 14th International Meeting on Cholinesterases and 8th International Conference on Paraoxonases, Bologna, Italija, 18.-21.9.2022.
  5. Bartolić, Evaluation of hydrazone-based compounds as potential drugs for treatment of Alzheimerā€™s disease, European School of Medicinal Chemistry- 41st Advanced Course of Medicinal Chemistry and ā€œE. Durantiā€ Seminar for PhD Students , Urbino, Italija, 3.-7.7. 2022.
  6. MatoÅ”ević, Design, synthesis and biological evaluation of cyclic biscarbamates as selective butyrylcholinesterase inhibitors in the treatment of Alzheimer`s disease, European School of Medicinal Chemistry- 41st Advanced Course of Medicinal Chemistry and ā€œE. Durantiā€ Seminar for PhD Students , Urbino, Italija, 3.-7.7. 2022.
  7. Bartolić, Hydrazone-based compounds evaluated as inhibitors of human cholinesterases, 17th International Symposium on Cholinergic Mechanisms (ISCM2022), 17th International Symposium on Cholinergic Mechanisms (ISCM2022), Dubrovnik, 8.-12.5.2022.
  8. Bosak, Evaluation of 4-aminoquinolines as potential anticholinesterase agents in the treatment of Alzheimer`s disease, 17th International Symposium on Cholinergic Mechanisms (ISCM2022), Dubrovnik, 8.-12.5.2022.
  9. MatoÅ”ević, Synthesis and biological evaluation of heterocyclic meta-biscarbamates, 17th International Symposium on Cholinergic Mechanisms (ISCM2022), Dubrovnik, 8.-12.5.2022.
  10. Opsenica, A. Bosak, A. MatoÅ”ević, K. Komatović, N. Maraković. 4-aminoquinolines, a privileged pharmacophore- from antimalarials to inhibition of cholinesterase. Book of Abstracts of the 27th Croatian Meeting of Chemists and Chemical Engineers (27HSKIKI). Veli LoÅ”inj, Hrvatska. 5.-8.10.2021. (abstract)
  11. MatoÅ”ević, A. Bosak. Application of NMR for monitoring the synthetic route and characterization of bisacrbamates. Book of abstracts of the Adriatic NMR Conference 2021. PrimoÅ”ten, Hrvatska. 13.-15.9.2021.; str. 46. (poster, abstract)
  12. Komatović, A. MatoÅ”ević, N. Terzić- Jovanović, A. Bosak, D. Opsenica. Adamantane based derivatives as reversible inhibitors of human AChE and BChE. FEBS Open Bio 11 (Suppl. 1); 45th FEBS Congress, Molecules of Life: Towards New Horizons. Ljubljana, Slovenija. 3.-8. 7. 2021.; str. 213. (poster)
  13. Bosak, A. MatoÅ”ević, A. Zandona, G. Å inko, K. Komatović, D. Opsenica. New 4-aminoquinoline-based cholinesterase inhibitors. FEBS Open Bio (Suppl. 1); 45th FEBS Congress, Molecules of Life: Towards New Horizons. Ljubljana, Slovenija. 3.ā€“8. 7. 2021.; str. 310.-311. (poster, abstract)
  14. MatoÅ”ević, A. Knežević, A. Bosak. Heterocyclic carbamates as potential drugs for the treatment of the neurodegenrative diseases. Book of abstracts of 29th European Colloquium on Heterocyclic Chemistry. Rouen, Francuska, 26-28. 4. 2021.; str. 143. (poster, sažetak)
  15. MatoÅ”ević, A. Bosak. Design, synthesis and biological evaluation of compounds as active drugs in the central and peripheral nervous system. Knjiga sažetaka 5. Simpozija studenata doktorskih studija PMF-a, Zagreb, Hrvatska, 24-25. 4. 2021.; str. 146. (poster, abstract)
List of publications

BioMol4ND

Presentations
  1. Bosak, Development of bioactive molecules for treatment of Alzheimerā€™s diseases, Symposium ā€žCell-BasedResearch inToxicologyandDrug Designā€, Zagreb, 26.1.2023.
  2. MatoÅ”ević, Design and synthesis of selective butyrylcholinesterase inhibitors as multi- target directed ligands in the treatment of Alzheimerā€™s disease, 6th Mini Symposium of Section of Medicinal and Pharmaceutical Chemistry, Zagreb, 22.11.2022.
  3. Bosak, Biscarbamates as cholinesterase inhibitors in the treatment of Alzheimerā€™s disease, 14th International Meeting on Cholinesterases and 8th International Conference on Paraoxonases, Bologna, Italija, 18.-21.9.2022.
  4. MatoÅ”ević, Design, synthesis and biological evaluation of biscarbamates as potential selective butyrylcholinesterase inhibitors for the treatment of Alzheimer`s disease, Joint IUBMB/FEBS Advanced Lecture Course “Molecular targets for anti-aging interventions”, Spetses Island, Grčka, 26.9.-1.10.2022.
  5. Bosak, Evaluation of 4-aminoquinolines as potential anticholinesterase agents in the treatment of Alzheimer`s disease, 17th International Symposium on Cholinergic Mechanisms (ISCM2022), Dubrovnik, 8.-12.5.2022.
  6. MatoÅ”ević, Synthesis and biological evaluation of heterocyclic meta-biscarbamates, 17th International Symposium on Cholinergic Mechanisms (ISCM2022), Dubrovnik, 8.-12.5.2022.
  7. Opsenica, 4-aminoquinolines, a privileged pharmacophore – from antimalarials to inhibition of cholinesterase, The 27th Croatian Meeting of Chemists and Chemical Engineers (27HSKIKI), Veli LoÅ”inj, 5.-8.10.2021.
  8. MatoÅ”ević, Design, synthesis and biological evaluation of biscarbamates, Hotel Academia, Zagreb. 2.11.2021.
  9. Bosak, Razvoj lijekova za tretman neurodegegnarativnih bolesti. Županijsko stručno vijeće učitelja I nastavnika biologije Krapinsko-zagorske županije,1. 7. 2021.
  10. MatoÅ”ević, Design, synthesis and biological evaluation of compounds as active drugs in the central and peripheral nervous system, 5th Symposium of PhD students, Faculty of science, Zagreb-a 24. 4. 2021.
Workshops/courses/webinars
  1. Bosak, A. MatoÅ”ević; FDA Clinical Investigator Training Course, U. S. Food & Drug Administration, 7.-8.12.2022. (on-line)
  2. Bartolić, A. Bosak, A. MatoÅ”ević; 1st Workshop in Mass Spectiometry in Life Sciences, Prirodoslovno-matematički fakultet, Zagreb, 24.-26.11.2022.
  3. Bartolić, A. MatoÅ”ević; Uvod u molekulsko modeliranje, Institut ā€œRuđer BoÅ”kovićā€, Zagreb, 2.-6.12.2021.
  4. Bartolić, Education workshop – Better skills for better jobs: excellent lab book for an excellent career, 11.-12.11.2021. (on-line)
  5. Bosak; seminar Uvod u upravljanje projektima, Bicro Biocentar, Zagreb, 26. 10. 2021.
  6. Bartolić, A. MatoÅ”ević; Practical workshop ā€œ Tekućinska kromatografija i spektrometrija masaā€, BICRO BIOCentar d.o.o., Zagreb 12.-13.10.2021.
  7. MatoÅ”ević SPICA Virtual Session The importance of Chromatography in the Development of Vaccines, 14.10.2021. (on-line)
  8. MatoÅ”ević; 2nd Symeres Precision Chemistry Conference on Tools for Molecular Recognition and Diagnostics, 12.-13.10.2021. (on-line)
  9. MatoÅ”ević; Reaxys webinar, Hrvatsko kemijsko druÅ”tvo i Elsevier, 23.04.2021.
  10. A. MatoÅ”ević, webinar, Intact and peptide level characterization of nanobodies by high resolution HPLC-MS/MS, 12.2.2021.

Valentina BuÅ”ić, Marija Bartolić, Anita Bosak, Ana MatoÅ”ević, Dajana GaÅ”o Sokač (from the left) Symposium ā€œCell-Based Research inToxicology and Drug Designā€, Zagreb, 26 Jan 2023

Ana MatoÅ”ević, 6th Mini Symposium of Section of Medicinal and Pharmaceutical Chemistry, Zagreb

Ana MatoÅ”ević (left) and M. Bartolić (right), Joint IUBMB/FEBS Advanced Lecture Course “Molecular targets for anti-aging interventions”, Spetses Island, Grčka

Marija Bartolić (left) and Ana MatoÅ”ević (right), European School of Medicinal Chemistry – 41st Advanced Course of Medicinal Chemistry and ā€œE. Durantiā€ Seminar for PhD Students , Urbino, Italija

Anita Bosak, 17th International Symposium on Cholinergic Mechanisms (ISCM2022), Dubrovnik

Ana MatoÅ”ević, 17th International Symposium on Cholinergic Mechanisms (ISCM2022), Dubrovnik

Marija Bartolić, 17th International Symposium on Cholinergic Mechanisms (ISCM2022), Dubrovnik

Ana MatoÅ”ević; predavanje na 5. Simpoziju studenata doktorskih studija PMF-a, Zagreb, Hrvatska

Ana MatoÅ”ević; postersko priopćenje na Adriatic NMR Conference 2021. PrimoÅ”ten, Hrvatska