Nikolina Maček Hrvat

Biochemistry and Organic Analytical Chemistry Unit

PhD / Senior Research Assistant

Place and date of birth

Zagreb, May 5 1983

Education

  • 2011-2015 PhD degree in Chemistry – Biochemistry, Faculty of Science, University of Zagreb, Croatia
  • 2001–2008 BSc degree in Biotechnology – Biochemical Engineering, Faculty of Food Technology and Biotechnology, University of Zagreb, Croatia

Work Experience

  • 09/2009 Biochemistry and Organic Analytical Chemistry Unit, Institute for Medical Research and Occupational Health, Zagreb
  • 06/2009-09/2009 Volunteer, Laboratory for Cellular Biochemistry; Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Zagreb

Fields of interest

Studying enzyme kinetics of the cholinesterase interactions with various organophosphates and newly developed oximes as the potential reactivators of the organophosphate inhibited cholinesterase activity, as well as bioscavenging potential of the acetylcholinesterase mutants in the event of organophosphate poisoning.

Additional training

  • 12/2016 “Basics of proteomics”, Zagreb, Croatia
  • 04/2016 “Principles of Toxicology”, Zagreb, Croatia
  • 04/2014 “InnoMol Proteomic Workshop”, Zagreb, Croatia
  • 09/2012–10/2012 “11th Greta Pifat-Mrzljak International School of Biophysics”, Primošten, Croatia
  • 06/2011–07/2011 “EUROTOX Basic Toxicology Course”, Belgrade, Serbia

Awards

2008 Award of the Croatian Society for Medical and Biological Engineering for the best graduation thesis in the area of biomedical engineering for academic year 2007/2008

Select Publications

  1. Maček Hrvat, Nikolina; Žunec, Suzana; Taylor, Palmer; Radić, Zoran; Kovarik, Zrinka (2016) HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants. Chemico-Biological Interactions 259, 148-153. DOI:10.1016/j.cbi.2016.04.023
  2. Katalinić, Maja; Maček Hrvat, Nikolina; Baumann, Krešimir; Morasi Piperčić, Sara; Makarić, Sandro; Tomić, Srđanka; Jović, Ozren; Hrenar, Tomica; Miličević, Ante; Jelić, Dubravko; Žunec, Suzana; Primožič, Ines; Kovarik, Zrinka (2016) A comprehensive evaluation of novel oximes in creation of butyrylcholinesterase-based nerve agent bioscavengers. Toxicology and Applied Pharmacology 310, 195-204. DOI:10.1016/j.taap.2016.09.015
  3. Kovarik, Zrinka; Maček Hrvat, Nikolina; Katalinić, Maja; Sit, Rakesh K.; Paradise, Alexander; Žunec, Suzana; Musilek, Kamil; Fokin, Valery V. Taylor, Palmer, Radić, Zoran (2015) Catalytic soman scavenging by Y337A/F338A acetylcholinesterase mutant assisted with novel site-directed aldoximes. Chemical Research in Toxicology 28 (5), 1036–1044. DOI:10.1021/acs.chemrestox.5b0060
  4. Kovarik, Zrinka; Maček, Nikolina; Sit, Rakesh K.; Radić, Zoran; Fokin, Valery V.; Sharpless, K. Barry; Taylor, Palmer (2013). Centrally acting oximes in reactivation of tabun-phosphoramidated AChE. Chemico-biological interactions 203 (1), 77–80. DOI:10.1016/j.cbi.2012.08.019

Memberships

  • Croatian Society of Biochemistry and Molecular Biology
  • Croatian Toxicological Society
  • Croatian Chemical Society

List of publications