Anita Bosak

Zagreb, 1974

• 2010 – PhD in Natural Sciences, Chemistry, Biochemistry and Medicinal Chemistry, Faculty of Science, University of Zagreb, Mentor: Z. Kovarik
• 2004 – Master of Science in Natural Sciences, scientific field of chemistry (biochemistry), Faculty of Science, University of Zagreb. Mentor: Vera Simeon .
• 1998 – B.A. in Chemical Engineering, Faculty of Science, University of Zagreb, Chemistry, Mentor: E. Reiner .

• 1999 − Institute for Medical Research and Occupational Health (IMI), Zagreb , Croatia (• 2023 – Scientific Advisor; • 2018 – 2023 Senior Research Associate; • 2013-2018 Research Associate; • 2001-2013 Assistant; • 1999-2001 Technical Associate)

Design, synthesis and biological evaluation of new compounds of different structural elements with possible biological activity towards targets involved in the treatment of neurodegenerative diseases

▪ In 2018, guest researcher, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Slovenia ▪ Laboratory for Molecular Neurobiology, Medical Faculty, Ljubljana, Slovenia 2007 ▪ Training course on Molecular Modeling and Computer Assisted Combinatorial Chemistry, International Center for Science and High Technology-UNIDO, Trieste, Italy , 2006 ▪ Eight International Summer School on Biophysics “Supramolecular Structure and Function”, Rovinj, 2003

• Annual Awards for Scientific Achievements , IMI (2020, 2017, 2013 and 2012)
• Annual Young Scientist Award, IMI, (2009)
• Annual Young Scientist Award, Croatian Society for Biochemistry and Molecular Biology (2009).
• Recognition for mentoring, Excellence Award for 2008 in the category of the best graduate theses, Rotary International, Rotary Club Varaždin (2009) FEBS scholarship for participation at the 33 th FEBS Congress & 11 th Conference , Athens, Greece, 2008.

• The Croatian Biochemical Society
• The Croatian Toxicological Society
• The Croatian Society of Natural Sciences

PROJECTS

Head

• 2020-2025 Development of bioactive treatment molecules for​ neurodegenerative diseases (HrZZ-IP-2020-02-9343)
• 2021-2025 Development career young people researcher ( Croatian Association of Journalists )
• 2016-2017 Kinetic evaluation PON1 interactions with pharmacological active carbamates (Ministry of Health of the Republic of Croatia, Croatian-Slovenian bilateral project )
• 2017-2020 Design, synthesis and evaluation of selective butyrylcholinesterase inhibitors, institutional project

Associate

• National projects: • 2023-2027. Meta-directed synthesis of inhibitors cholinesterase supported by machine learning ( hrZZ , IP-2022-10). • 2018-2022. Analysis of butyrylcholinesterase interactions with new inhibitors and reactivators ( HrZZ , IP-2018-01-7683); • 2017-2021. Activity and in in silico directed design of small bioactive molecules ( HrZZ , IP-2016-06-3775); •2014-2018. Design, synthesis and evaluation of new antidotes for poisoning with nerve agents and pesticides ( HrZZ , IP-2013-11-4307); • 2007-2013. Interactions of organophosphates , carbamates and selected ligands with esterases (MZO RH); • 2002-2006. Mechanism of interaction between esterases and organophosphorus compounds (MZOS RH); • 1996-2002. Esters and organophosphorus compounds (MZOS RH)
• International projects: • 2015-2016. Design of new centrally active reactivators cholinesterase (Croatian-French “Cogit ” collaborative program Hubert Curien; partner University of Rouen, Mont Saint Aignan, France); • 2013-2016. BChE reactivators for detoxification of nerve agents and pesticides in human tissue (NIH project, partner UCSD); • 2010-2012. Optimization of nepyridinium oxime for OP hydrolysis in BChE -assisted plasma (NIH project, partner UCSD) • 2005-2008. Antidotes for the treatment of nerve gas poisoning (NATO Security through science program: Reintegration grant EAP.RIG 981791)