Tamara Zorbaz

Jedinica za biokemiju i organsku analitičku kemiju

mag. med. biochem. / Poslijedoktorand

Mjesto i datum rođenja

Zagreb, 2. srpnja 1990.

Obrazovanje

  • 2015.-2018. Prirodoslovno-matematički fakultet, Sveučilište u Zagrebu Poslijediplomski doktorski studij kemije, smjer biokemija; Doktorski rad „Novi pristup analizi oksima dizajniranih za zaštitu središnjeg živčanog sustava pri trovanju organofosfornim spojevima“, mentorica dr. sc. Zrinka Kovarik.
  • 2009.-2014. Farmaceutsko-biokemijski fakultet, Sveučilište u Zagrebu, smjer medicinska biokemija; Diplomski rad „Učinak inhibitora Hsp90, 17-DMAG-a, na ekspresiju galektina-3”, mentorica prof. dr. sc. Jerka Dumić.
  • 2005.-2009. Gimnazija Lucijana Vranjanina, jezični smjer.

Radno iskustvo

  • Institut za medicinska istraživanja i medicinu rada, Zagreb: asistent (2015.-2018.), poslijedoktorand (2019.-)
  • Farmaceutsko-biokemijski fakultet, Sveučilište u Zagrebu, Zavod za biokemiju i molekularnu biologiju: izrada diplomskog i volontiranje (travanj-studeni 2014.)

Područja znanstvenog / stručnog interesa

Mehanizmi interakcije kolinesteraza i organofosfornih spojeva (OP), reaktivacija OP-inhibiranih kolinesteraza, biokemijska i farmakološka procjena novih reaktivatora.

Znanstvenostručna usavršavanja

  • Cognition and Action Group (COGNAC G), Le Centre national de la recherche scientifique (CNRS MD, UMR 8257), Université Paris Descartes, Pariz, Francuska: dvomjesečni boravak u istraživačkoj grupi pod vodstvom dr. sc. Erica Krejcija (rujan-listopad 2016.)

Tečajevi/radionice:

  • Adverse outcome pathways (AOP): The how and why of development & application workshop (Faculty of Science, University of Zagreb, Croatia, December 2018)
  • Mendeley Reference Manager course (IMROH, Zagreb, Croatia, November 2018)
  • FEBS workshop on molecular life science education (University of Zagreb, Croatia, April 2018)
  • Communication skills (Faculty of Science, University of Zagreb, Croatia, June 2017)
  • Using 3R approach in the work with laboratory animals (CroLASA i HIIM; Zagreb, Croatia, October 2015)
  • Managing the knowledge, intellectual property, transfer of the technology and innovations workshop (Faculty of Science, University of Zagreb, Croatia, July 2015)
  • Symposium and workshop on microscale thermophoresis (IntegraLife FP7 RegPot, University of Zagreb, Croatia, July 2015)
  • The InnoMol molecular interactions Workshop (Ruđer Bošković Institute, Zagreb, Croatia, June 2015)
  • Skeletal muscle research from cell to human Workshop (Faculty of Medicine, University of Ljubljana, Slovenia, May 2015)
  • Novel diagnostic and therapeutic approach in complex genetic disease, International CEEPUS Summer School (Portorož, Slovenia, August 2014)
  • Parathyroid  multidisciplinary approach to diagnostics and monitoring of surgery and therapy success training course (Faculty of the Pharmacy and Biochemistry, University of Zagreb, Croatia, June 2013)

Nagrade i priznanja

  • Travel Award for XVIth International Symposium on Cholinergic Mechanisms, Rehovot, Israel (2019.)
  • Poster Award at the HDBMB2019 Congress Crossroads in Life Sciences, Lovran, Croatia (2019.)
  • Travel fellowship for 13th International Meeting on Cholinesterases and the 7th International Conference on Paraoxonases, Hradec Králové, Czech Republic (2018.)
  • Poster Award at the 13th International Meeting on Cholinesterases and the 7th International Conference on Paraoxonases, Hradec Králové, Czech Republic (2018.)
  • FEBS Junior travel fellowship for FEBS3+ conference From molecules to living systems, Siófok, Hungary (2018.)
  • YSF grant for participation at the 17th YSF and 42nd FEBS Congress, Jerusalem, Israel (2017.)
  • Poster Award at the 16th Medical Chemical Defence Conference, Munich, Germany (2017.)
  • ISN/IBRO-PERC Young Investigator Poster Prize, XVth International Symposium on Cholinergic Mechanisms, Marseille, France (2016.)
  • Scholarship of the French Government for a short-term professional development (2016.)

Istaknute publikacije

  1. T. Zorbaz, P. Mišetić, N. Probst, S. Žunec, A. Zandona, G. Mendaš, V. Micek, N. Maček Hrvat, M. Katalinić, A. Braïki, L. Jean, P.-Y. Renard,V. Gabelica Marković, Z. Kovarik. Pharmacokinetic evaluation of brain penetrating morpholine-3-hydroxy-2-pyridine oxime as an antidote for nerve agent poisoning. ACS Chemical Neuroscience, 2020, accepted. https://pubs.acs.org/doi/10.1021/acschemneuro.0c00032
  2. T. Zorbaz, A. Braïki, N. Maraković, J. Renou, E. de la Mora, N. Maček Hrvat, M. Katalinić, I. Silman, J. L. Sussman, G. Mercey, C. Gomez, R. Mougeot, B. Pérez, R. Baati, F. Nachon, M. Weik, L. Jean, Z. Kovarik, P.-Y. Renard. Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration. Chemistry – A European Journal, 2018, 24, 9675-91. https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201801394
  3. T. Zorbaz, D. Malinak, N. Maraković, N. Maček Hrvat, A. Zandona, M. Novotny, A. Skarka, R. Andrys, N. Benkova, O. Soukup, M. Katalinić, K. Kuca, Z. Kovarik, K. Musilek. Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents. Journal of Medicinal Chemistry, 2018, 61, 10753-66. https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.8b01398?journalCode=jmcmar
  4. T. Zorbaz, D. Malinak, K. Kuca, K. Musilek, Z. Kovarik. Butyrylcholinesterase inhibited by nerve agents is efficiently reactivated with chlorinated pyridinium oximes. Chemico-Biological Interactions, 2019, 307, 16-20. https://www.sciencedirect.com/science/article/abs/pii/S0009279719303941?via%3Dihub
  5. N. Maček Hrvat, T. Zorbaz, G. Šinko, Z. Kovarik. The estimation of oxime efficiency is affected by the experimental design of phosphylated acetylcholinesterase reactivation. Toxicology Letters, 2018, 293, 222-228. https://www.sciencedirect.com/science/article/pii/S0378427417314819?via%3Dihub
  6. B. L. d’Incamps, T. Zorbaz, D. Dingova, E. Krejci, P. Ascher. Stoichiometry of the heteromeric nicotinic receptors of the Renshaw cell. The Journal of Neuroscience, 2018, 38 (21), 4943-4956 http://www.jneurosci.org/content/38/21/4943

Članstva u stručnim udrugama / društvima

  • Hrvatsko društvo za biokemiju i molekularnu biologiju (HDBMB)
  • The International Society for Neurochemistry (ISN)

Popis publikacija