Independent Researcher: Aleksandra Fučić, genotoxicologist

Research

Aleksandra Fučić, PhD, investigates genome damage and health risks associated with occupational and environmental exposure to ionising radiation and chemical agents. Genome and/or cell damage assessment is done using the complexity theory and systems biology. As a member of the Implementation Group on Human Biomonitoring, she is particularly focused on using biomonitoring for the prevention of diseases associated with exposure to radiochemical environment. By participating in European studies on biomonitoring, a possibility of joint work of EU member state laboratories is explored for the purpose of harmonised studies on lead and phthalate concentrations in mothers and children.

The following topics are investigated within teams involving many local and foreign experts who work on both local and international projects:

  • how a determined genome and cell damage may be used in the assessment of a potential increased risk of cancer;
  • using systems biology, the existing knowledge of xenobiotics’ genotoxic activity and the results of biomonitoring are linked to improve their predictivity in detecting those populations that have a particularly increased risk of cancer development;
  • genome damage in children transplacentally exposed to radiation, chemical agents and drugs;
  • animal models are used to investigate developmental genotoxicology;
  • the incidence of those cancers whose aetiology may be related to exposure to environmental factors is studied in collaboration with epidemiologists and oncologists;
  • long-term effect of different doses of ionising radiation on human genome;
  • effect of diet and transplacental pollutants from food on genome damage in mothers and newborns

Projects

Domestic:

International:

  • Human Micronucleus Collaborative Study, HUMN (M. Fenech, CSIRO, Australia 1995.-
  • Cytogenetic Biomarkers and Human Cancer Risk” (coordinator H. Norrpa, Finland European Commission, FP5) 2001-2004
  • “European network on children susceptibility and exposure to environmental genotoxicants”(coordinator : L. Knudsen, Denmark, European Commission, FP5), 2002-2005
  • Policy interpretation network on children’s health and environment (coordinator P. van den Hazel, Netherlands, European Commission, FP5) , 2002-2005
  • Health and Environment Network (coordinator: A. Bartonova, Norway European Commission, FP6) 2006-2010
  • Newborns and genotoxic risks: Development and application of biomarkers of dietary exposure to genotoxic and immunotoxic chemicals and of biomarkers of early effects, using mother-child birth cohorts and biobanks, (coordinator J. Kleinjans, Netherlands, European Commission, FP6) 2005-
  • Expert team to support biomonitoring in Europe (coordinator R. Joas, Germany, European Commission, FP6) 2006-2009
  • European Coordination action on human biomonitoring (coordinator R. Joas, Germany, European Commission, FP 7) 2009-
  • Demonstration of a study to coordinate and perform human biomonitoring on a European scale,(LIFE09 ENV) 2010-