
Tamara Zorbaz
Biochemistry and Organic Analytical Chemistry Unit
Master of Medical Biochemistry / Postdoctoral Researcher
- Research Gate: https://www.researchgate.net/profile/Tamara_Zorbaz2
- LinkedIn: https://www.linkedin.com/in/tamara-zorbaz-6767bb144/
Place and date of birth
Zagreb, 2 July 1990
Education
- 2015-2018: Faculty of Science, University of Zagreb Study: Postgraduate doctoral study in Chemistry, Biochemistry Supervisor: Dr Zrinka Kovarik
- 2009-2014: Faculty of Pharmacy and Medical Biochemistry, University of Zagreb Study: Master in Medical Biochemistry and Laboratory Medicine Thesis: “The effect of Hsp90 inhibitor, 17-DMAG-a, on the expression of galectin-3”, under the supervision of Professor Jerka Dumić
- 2005-2009: Gimnazija Lucijana Vranjanina
Work Experience
- Institute for Medical Research and Occupational HeaIth (IMROH), Zagreb, Croatia: Research Assistant (2015-2018), Postdocotral Researcher (2019-)
- Cognition and Action Group (COGNAC G), Le Centre national de la recherche scientifique (CNRS MD, UMR 8257), Université Paris Descartes, Paris, France: Research stay (September-October 2016, 2 mo)
- Department of Biochemistry and Molecular Biology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia: Master’s degree thesis research and volunteering (April-November 2014)
Fields of interest
Mechanisms of interaction between cholinesterases and organophosphorus (OP) compounds, reactivation of OP-inhibited cholinesterases, biochemical and pharmacological evaluation of novel antidotes.
Additional training
COURSES/WORKSHOPS/TRAININGS:
- Adverse outcome pathways (AOP): The how and why of development & application workshop (Faculty of Science, University of Zagreb, Croatia, December 2018)
- Mendeley Reference Manager course (IMROH, Zagreb, Croatia, November 2018)
- FEBS workshop on molecular life science education (University of Zagreb, Croatia, April 2018)
- Communication skills (Faculty of Science, University of Zagreb, Croatia, June 2017)
- Using 3R approach in the work with laboratory animals (CroLASA i HIIM; Zagreb, Croatia, October 2015)
- Managing the knowledge, intellectual property, transfer of the technology and innovations workshop (Faculty of Science, University of Zagreb, Croatia, July 2015)
- Symposium and workshop on microscale thermophoresis (IntegraLife FP7 RegPot, University of Zagreb, Croatia, July 2015)
- The InnoMol molecular interactions Workshop (Ruđer Bošković Institute, Zagreb, Croatia, June 2015)
- Skeletal muscle research from cell to human Workshop (Faculty of Medicine, University of Ljubljana, Slovenia, May 2015)
- Novel diagnostic and therapeutic approach in complex genetic disease, International CEEPUS Summer School (Portorož, Slovenia, August 2014)
- Parathyroid multidisciplinary approach to diagnostics and monitoring of surgery and therapy success training course (Faculty of the Pharmacy and Biochemistry, University of Zagreb, Croatia, June 2013)
Awards
- Travel Award for XVIth International Symposium on Cholinergic Mechanisms, Rehovot, Israel (2019)
- Poster Award at the HDBMB2019 Congress Crossroads in Life Sciences, Lovran, Croatia (2019)
- Travel fellowship for 13th International Meeting on Cholinesterases and the 7th International Conference on Paraoxonases, Hradec Králové, Czech Republic (2018)
- Poster Award at the 13th International Meeting on Cholinesterases and the 7th International Conference on Paraoxonases, Hradec Králové, Czech Republic (2018)
- FEBS Junior travel fellowship for FEBS3+ conference From molecules to living systems, Siófok, Hungary (2018)
- YSF grant for participation at the 17th YSF and 42nd FEBS Congress, Jerusalem, Israel (2017)
- Poster Award at the 16th Medical Chemical Defence Conference, Munich, Germany (2017)
- ISN/IBRO-PERC Young Investigator Poster Prize, XVth International Symposium on Cholinergic Mechanisms, Marseille, France (2016)
- Scholarship of the French Government for a short-term professional development (2016)
Select Publications
- T. Zorbaz, P. Mišetić, N. Probst, S. Žunec, A. Zandona, G. Mendaš, V. Micek, N. Maček Hrvat, M. Katalinić, A. Braïki, L. Jean, P.-Y. Renard,V. Gabelica Marković, Z. Kovarik. Pharmacokinetic evaluation of brain penetrating morpholine-3-hydroxy-2-pyridine oxime as an antidote for nerve agent poisoning. ACS Chemical Neuroscience, 2020, accepted. https://pubs.acs.org/doi/10.1021/acschemneuro.0c00032
- T. Zorbaz, A. Braïki, N. Maraković, J. Renou, E. de la Mora, N. Maček Hrvat, M. Katalinić, I. Silman, J. L. Sussman, G. Mercey, C. Gomez, R. Mougeot, B. Pérez, R. Baati, F. Nachon, M. Weik, L. Jean, Z. Kovarik, P.-Y. Renard. Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration. Chemistry – A European Journal, 2018, 24, 9675-91. https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201801394
- T. Zorbaz, D. Malinak, N. Maraković, N. Maček Hrvat, A. Zandona, M. Novotny, A. Skarka, R. Andrys, N. Benkova, O. Soukup, M. Katalinić, K. Kuca, Z. Kovarik, K. Musilek. Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents. Journal of Medicinal Chemistry, 2018, 61, 10753-66. https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.8b01398?journalCode=jmcmar
- T. Zorbaz, D. Malinak, K. Kuca, K. Musilek, Z. Kovarik. Butyrylcholinesterase inhibited by nerve agents is efficiently reactivated with chlorinated pyridinium oximes. Chemico-Biological Interactions, 2019, 307, 16-20. https://www.sciencedirect.com/science/article/abs/pii/S0009279719303941?via%3Dihub
- N. Maček Hrvat, T. Zorbaz, G. Šinko, Z. Kovarik. The estimation of oxime efficiency is affected by the experimental design of phosphylated acetylcholinesterase reactivation. Toxicology Letters, 2018, 293, 222-228. https://www.sciencedirect.com/science/article/pii/S0378427417314819?via%3Dihub
- B. L. d’Incamps, T. Zorbaz, D. Dingova, E. Krejci, P. Ascher. Stoichiometry of the heteromeric nicotinic receptors of the Renshaw cell. The Journal of Neuroscience, 2018, 38 (21), 4943-4956 http://www.jneurosci.org/content/38/21/4943
Memberships
- Croatian Society of Biochemistry and Molecular Biology (HDBMB)
- The International Society for Neurochemistry (ISN)