Maja Peraica

Toxicology Unit

MD; PhD / Head of Unit

Place and date of birth

14 October 1956

Education

  • School of Medicine, University of Zagreb (1980)
  • School of Medicine, University of Padua, Italy (1994- “Il fenilmetnosulfonil fluorido promouve la neuropatia periferica e quella spinale innescate dal diisopropil fluorofosfato nella gallina”, mentor prof. dr. Marcello Lotti)
  • Masters Degree – Faculty of Sciences, University of Zagreb (1986- „Učinak okratoksina A na neke proteine bubrega“, mentor prof.dr. Radovan Pleština) Postdoc Study of Occupational Health, School of Medicine, University of Zagreb (1987-1989)
  • Doctoral Thesis – University of Zagreb (1992- „Studies on organophosphate induced delayed polyneuropathy“, mentor prof. dr. Marcello Lotti)

Work Experience

  • 1980-1981 – obligatory medical training
  • 1982-1993 – scientific assistant in the Institute for Medical Research and Occupational Health in Zagreb
  • 1993-1996 – researcher in the Institute of Occupational Health in Padua, Italy since
  • 1996 – researcher in the Institute for Medical Research and Occupational Health in Zagreb
  • 2011 – Scientific adviser with permanent position
  • 2011 – Head of the Unit of Toxicology

Fields of interest

Toxicology of mycotoxins

Additional training

  • 1989-1990 – Fellowship of the Foreign Office of Republic of Italy for the research in the Institute of Occupational Health, Padua, Italy
  • 1991-1993 – Fellowship of European Science Foundation for the research at the same institute
  • 1994-1995 – Fellowship of School of Medicine, University of Padua, Italy

Awards

  • Annual award of the Institute for Medical Research and Occupational Health in 2005. for the publication with the highest number of citations until the end of year 2004: „Peraica M, Radić B, Lucić A, Pavlović M. Toxic effects of mycotoxins in humans. Bull WHO 1999; 77: 754-766.”
  • Annual award of the Institute for Medical Research and Occupational Health in 2006 for the highest number of scientific papers published in 2005 in journals referred in Current Contents.
  • Annual award of the Institute for Medical Research and Occupational Health in 2007 for the scientific paper published in Archives of Industrial Hygiene and Toxicology that is cited at least 7 times until the end of year 2006: „Peraica M., Domijan A-M. Contamination of food with mycotoxins and human health. Arh Hig Rada Toksikol 2001; 52: 23-35.“
  • Annual award of the Institute for Medical Research and Occupational Health in 2008 for the scientific paper published in journal with the highest impact factor in the category in year 2007: „Pfohl-Leszkowicz A, Tozlovanu M, Manderville R, Peraica M, Castegnaro M, Stefanović V. New molecular and field evidence for the implication of mycotoxins but not aristolochic aci din human nephropathy and urinary tract tumor. Molec Nutr Food Res 2007; 51: 1131-1146.“
  • Annual award of the Institute for Medical Research and Occupational Health in 2009 for the publication with the highest number of citations until the end of year 2008: „Peraica M, Radić B, Lucić A, Pavlović M. Toxic effects of mycotoxins in humans. Bull WHO 1999; 77: 754-766.”
  • Annual award of the Institute for Medical Research and Occupational Health in 2012 for the publication published in Archives of Industrial Hygiene and Toxicology cited at least 7 times until the end of year 2011: „Domijan A-M, Peraica M, Fuchs R, Lucić A, Radić B, Balija M, Bosanac I, Grgičević D. Ochratoxin A in blood of healthy population in Zagreb. Arh Hig Rada Toksikol 1999: 50: 263-271.“
  • Annual award of the Institute for Medical Research and Occupational Health in 2015 for the scientific paper published in Archives of Industrial Hygiene and Toxicology cited at least 7 times until the end of year 2014: „Flajs D, Peraica M. toxicological properties of citrinin. Arh Hig Rada Toksikol 2009; 60:457-464.“
  • Annual award of the Institute for Medical Research and Occupational Health in 2015 for the scientific paper with the highest number of citations until the end of year 2014: „Peraica M, Radić B, Lucić A, Pavlović M. Toxic effects of mycotoxins in humans. Bull WHO 1999; 77: 754-766.”

Select Publications

  1. Fuchs R, Hult K, Peraica M, Radić B, Pleština R. Conversion of ochratoxin C into ochratoxin A in vivo. Appl Environ Microbiol 1984; 48: 41- 42.
  2. Hult K, Fuchs R, Peraica M, Pleština R, Čeović S. Screening for ochratoxin A in blood by flow injection analysis. J Appl Toxicol 1984; 4: 326-329.
  3. Fuchs R, Radić B, Peraica M, Hult K, Pleština R. Enterohepatic circulation of ochratoxin A in rats. Period Biol 1988; 90: 39-42.
  4. Moretto A, Capodicasa E, Peraica M, Lotti M. Age sensitivity to organophosphate-induced delayed polyneuropathy. Biochemical and toxicological studies in developing chicks. Biochem Pharmacol 1991; 41: 1497-1504.
  5. Moretto A, Bertolazzi M, Capodicasa E, Peraica M, Richardson RJ, Scapellato M-L, Lotti M. Phenylmethanesulfonyl fluoride elicits and intensifies the clinical expression of neuropathic insults. Arch Toxicol 1992; 66: 67-72.
  6. Peraica M, Capodicasa E, Moretto A, Lotti M. Organophosphate polyneuropathy in chicks. Biochem Pharmacol 1993; 45: 131-135.
  7. Moretto A, Capodicasa E, Peraica M, Lotti M. Phenylmethanesulfonyl fluoride delays the recovery from crush of peripheral nerves in hens. Chem Biol Interactions 1993; 457-462.
  8. Lotti M, Moretto A, Capodicasa E, Bertolazzi M, Peraica M, Scapellato M-L. Interactions between Neuropathy target esterase and its inhibitors and the development of polyneuropathy. Toxicol Appl Pharmacol 1993; 122: 165-171.
  9. Lotti M, Moretto A, Bertolazzi M, Peraica M, Fioroni F. Organophosphate polyneuropathy and neuropathy target esterase: studies with methamidophos and its resolved optical isomers. Arch Toxicol 1995; 69: 330-336.
  10. Peraica M, Moretto A, Lotti M. Selective promotion by phenylmethanesulfonyl fluoride of peripheral and spinal cord neuropathies initiated by diisopropyl phosphofluoridate in the hen. Toxicol Lett 1995; 80: 115-121.
  11. Radić B, Radulović M, Peraica M, Fuchs R. Effects of some mono- and bis-pyridinium oximes in carbamate poisoning. Acta Pharm 1995; 45: 91-96.
  12. Radić B, Fuchs R, Peraica M, Lucić A. Ochratoxin A in human sera in the area with endemic nephropathy in Croatia. Toxicol Lett 1997; 91: 105-109.
  13. Peraica M, Radić B, Lucić A, Pavlović M. Toxic effects of mycotoxins in humans. Bull WHO 77 (1999) 754-766.
  14. Peraica M, Domijan A-M, Fuchs R, Lucić A, Radić B. The occurence of ochratoxin A in blood in general population in Croatia. Toxicol Lett 1999; 110: 105-112.
  15. Peraica M, Domijan A-M, Matašin M, Lucić A, Radić B, Delaš F, Horvat M, Bosanac I, Balija M, Grgičević D. Variations of ochratoxin A concentration in the blood of healthy population in some Croatian cities. Arch Toxicol 2001; 75: 410-414.
  16. Škare D, Radić B, Lucić A, Peraica M, Domijan A-M, Milković-Kraus S, Bradamante V, Jukić I. Adamantyl tenocyclidines – adjuvant therapy in poisoning with organophosphorous compounds and carbamates. Arch Toxicol 2002; 76: 173-177.
  17. Stoev SD, Daskalov H, Radić B, Domijan A-M, Peraica M. Spontaneous mycotoxic nephropathy in Bulgarian chickens with unclarified mycotoxin aetiology. Vet Res 2002; 33: 83-93.
  18. Domijan A-M, Peraica M, Miletić-Medved M, Lucić A, Fuchs R. Two different clean-up procedures for liquid chromatographic determination of ochratoxin A in urine. J Chromatography B 2003; 798: 317-21.
  19. Pepeljnjak S, Slobodnjak Z, Šegvić M, Peraica M, Pavlović M. The ability of fungal isolates from human lung aspergilloma to produce mycotoxins. Hum Exp Toxicol 2004; 23:15-19.
  20. Stoev SD, Stefanov M, Denev S, Radić B, Domijan A-M, Peraica M. Experimental mycotoxicosis in chickens induced by ochratoxin A and penicillic acid and intervention with natural plant extracts. Veterinary Research Communications 2004; 28:727-746.
  21. Domijan A-M, Peraica M, Žlender V, Cvjetković B, Jurjević Ž, Topolovec-Pintarić S, Ivić D. Seed-borne fungi and ochratoxin A contamination of dry beans (Phaseolus vulgaris L.) in the Republic of Croatia. Food Chem Toxicol 2005;43: 427-432.
  22. Domijan A-M, Peraica M, Jurjević Ž, Ivić D, Cvjetković B. Fumonisin B1, fumonisin B2, zearalenone and ochratoxin A contamination of maize in Croatia. Food Add and Contam 2005; 22: 677-681
  23. Miletić-Medved M, Domijan A-M, Peraica M. Recent data on endemic nephropathy and related urothelial tumors in Croatia. Wien Klin Wochenschr 2005; 117: 604-609.
  24. Fuchs R, Peraica M. Ochratoxin A in human kidney diseases. Food Addit Contam 2005 (Suppl 1) 53-57.
  25. Domijan A-M, Želježić D, Kopjar N, Peraica M. Standard and Fpg-modified comet assay in kidney cells of ochratoxin A- and fumonisin B- treated rats. Toxicology 2006; 222: 53-59.
  26. Želježić D, Domijan A-M, Peraica M. DNA damage by ochratoxin A in rat kidney assessed by the alkaline comet assay. Brazil J Med Biolog Res 2006;39,1563-1568.
  27. Domijan A-M, Želježić D, Milić M, Peraica M. Fumonisin B1: oxidative status and DNA damage in rats. Toxicology 2007; 232: 163-169.
  28. Galvano F, Ritieni A, La Fauci L, Li Vloti G, Di Giacomo C, Vanella L, Marcantoni C, Peraica M. Cereals consumption and risk for renal cell carcinoma: Can be hypothesized a role of mycotoxins? Int J Cancer 2007;121:2116-2117.
  29. Domijan A-M, Peraica M, Lucić Vrdoljak A, Radić B, Žlender V, Fuchs R. The involvement of oxidative stress in ochratoxin A and fumonisin B1 toxicity in rats. Mol Nutr Food Res 2007;51:1147-1151.
  30. Pfohl-Leszkowicz A, Tozlovanu M, Manderville R, Peraica M, Castegnaro M, Stefanović V. New molecular and field evidences for the implication of mycotoxins but not aristolochic acid in human nephropathy and urinary tract tumor. Mol Nutr Food Res 2007;51:1131-2246.
  31. Rumora L, Domijan A-M, Žanić Grubišić T, Peraica M. Mycotoxin fumonisin B1 alters cellular redox balance and signaling pathways in rat liver and kidney. Toxicology 2007; 242: 31-38.
  32. Peraica M, Ljubanović D, Želježić D, Domijan A-M. The effect of single dose of fumonisin B1 on rat kidney. Croat Chem Acta 2008; 81:119-124.
  33. Peraica M, Domijan A-M, Miletić-Medved M, Fuchs R. The involvement of mycotoxins in the development of endemic nephropathy. Wien Klin Wochenschr 2008; 120: 402-407.
  34. Peraica M, Domijan A-M, Šarić M. Mycotoxic and aristolochic acid theories of the development of endemic nephropathy. Arhiv Hig Rada Toksikol 2008; 59, 59-65.
  35. Domijan A-M, Želježić D, Peraica M, Kovačević G, Gregorović G, Krstanec Ž, Horvatin K, Kalafatić M. Early toxic effects of fumonisin B1 in rat liver. Hum Exper Toxicol 2008; 27: 895-900.
  36. Flajs D, Domijan A-M, Ivić D, Cvjetković B, Peraica M. ELISA and HPLC analysis of ochratoxin A in red wines of Croatia. Food Control 2009; 20: 590-592.
  37. Ivić D, Domijan A-M, Peraica M, Cvjetković B. Fumonisin B1 and zearalenone contamination of wheat in Croatia and influence of fungicide treatments. Phytoprotection 2009; 90:31-34.
  38. Žlender V, Breljak D, Ljubojevic M, Flajs D, Balen D, Brzica H, Domijan A-M, Peraica M, Fuchs R, Anzai N, Sabolic I. Low doses of ochratoxin A upregulate the protein expression of organic anion transporters Oat1, Oat2, Oat3 and Oat5 in rat kidney cortex. Toxicol Appl Pharmacol 2009; 239: 284-296.
  39. Flajs D, Peraica M. Toxicological features of citrinin. Arh Hig Rada Toksikol 2009; 60: 457-464. (doi: 10.2478/10004-1254-60-2009-1992)
  40. Peraica M, RAšić D. The impact of mycotoxicoses on human history. Arh Hig Rada Toksikol 2012; 63: 511-516.
  41. Jurjević Ž, Peterson SW, Solfrizzo M, Peraica Z. Sterigmatocystin production by nine newly described Aspergillus species in section Versicolores grown on two different media. Mycotoxin Res 2013; 29: 141-5. (doi: 101007/Sl2550-013-0160-4)
  42. Peraica M, Richter D, Rašić D. Mycotoxicoses in children. Arhiv Hig Rada Toksikol 2014; 63: 347-363. doi.: 10.2478/10004-1254-65-2014-2557
  43. Šegvić Klarić M, Jakšić Despot D, Kopjar N, Rašić D, Kocsube S, Varga J, Peraica M. Cytotoxic and genotoxic potencies of single and combined spore extracts of airborne OTA-producing and OTA-non-producing Aspergilli in human lung A549 cells. Ecotoxicol Environm Hlth 2015; 120: 206-214.

Memberships

As an internationally renowned expert for mycotoxins, I was invited to be the member of Work Group of European Food Safety Agency for toxins of Aspergillus moulds (2011-2013) that prepared risk assessment for human and animal exposure to citrinin and sterigmatocystin.

  • Since 2012 – member of Work Group for Opinion on Mycotoxins in feed of Croatian Food Agency
  • Since 2010 – President of Croatian Society of Toxicology
  • Since 2001 – Member of Ethical Committee of Institute for Medical Research and Occupational Health

Other

  • Since 2004 – Editor-in-chief of the journal “Glasnik Hrvatskoga katoličkog liječničkog društva”
  • Since 2007 – Editor-in-chief of the journal “Bruška zora”
  • Editor of several issues in library “Signa Cordis”
  • Editor of several books and monographs on bioethics

List of publications